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Refining Processes for the Co-Development of Genome-Based Therapeutics and Companion Diagnostic Tests
Many drug developers have examined new strategies for creating efficiencies in their development processes, including the adoption of genomics-based approaches. Genomic data can identify new drug targets for both common and rare diseases, can predict which patients are likely to respond to a specific treatment, and has the potential to significantly reduce the cost of clinical trials by reducing the number of patients that must be enrolled in order to demonstrate safety and efficacy. A key component of the approval of targeted therapeutics is the ability to identify the population of patients who will benefit from treatment, and this has largely hinged on the co-development and co-submission...
Patients Charting the Course
As past, current, or future patients, the public should be the health care system's unwavering focus and serve as change agents in its care. Taking this into account, the quality of health care should be judged not only by whether clinical decisions are informed by the best available scientific evidence, but also by whether care is tailored to a patient's individual needs and perspectives. However, too often it is provider preference and convenience, rather than those of the patient, that drive what care is delivered. As part of its Learning Health System series of workshops, the Roundtable on Value & Science-Driven Health Care hosted a workshop to assess the prospects for improving health and lowering costs by advancing patient involvement in the elements of a learning health system.
Innovations in Service Delivery in the Age of Genomics
New discoveries in genomics-that is, the study of the entire human genome-are changing how we diagnose and treat diseases. As the trend shifts from genetic testing largely being undertaken for rare genetic disorders to, increasingly, individuals being screened for common diseases, general practitioners, pediatricians, obstetricians/gynecologists, and other providers need to be knowledgeable about and comfortable using genetic information to improve their patients' health. To address these changes, the Roundtable on Translating Genomic-Based Research for Health held the public workshop "Innovations in Service Delivery in the Age of Genomics" on July 27, 2008.
Enabling Precision Medicine
Those involved in the drug development process face challenges of efficiency and overall sustainability due in part to high research costs, lengthy development timelines, and late-stage drug failures. Novel clinical trial designs that enroll participants based on their genetics represent a potentially disruptive change that could improve patient outcomes, reduce costs associated with drug development, and further realize the goals of precision medicine. On March 8, 2017, the Forum on Drug Discovery, Development, and Translation and the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted the workshop Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development. Participants examined successes, challenges, and possible best practices for effectively using genetic information in the design and implementation of clinical trials to support the development of precision medicines, including exploring the potential advantages and disadvantages of such trials across a variety of disease areas. This publication summarizes the presentations and discussions from the workshop.
Notebooks of a Chile Verde Smuggler
In a collection of poetry, prose, journal entries, and even a screenplay, the Chicano poet fixes his gaze on his own life and times, invoking childhoods, neighborhoods, historical revisions, misfits and outcasts.
Mi Vida Loca, My Crazy Life
This book is about what life was like in the twentieth century as experienced by one who was born in a small farming and ranching community during the Great Depression and grew up with, lived among, played with, and worked with people of Hispanic descent like himself, and then in a small New Mexico city among people whose descendants came mostly from Europe, Asia, Central and South America, and the Indigenous People who were here first. Almost his entire life and career were spent living among, and/or working with, and for the people of the Navajo, Zuni, Acoma, Laguna, Apache, Hoopa and Yurok Tribes and served in an Administrative capacity with the Department of the Interior, Bureau of India...
Engineering a Learning Healthcare System
Improving our nation's healthcare system is a challenge which, because of its scale and complexity, requires a creative approach and input from many different fields of expertise. Lessons from engineering have the potential to improve both the efficiency and quality of healthcare delivery. The fundamental notion of a high-performing healthcare system-one that increasingly is more effective, more efficient, safer, and higher quality-is rooted in continuous improvement principles that medicine shares with engineering. As part of its Learning Health System series of workshops, the Institute of Medicine's Roundtable on Value and Science-Driven Health Care and the National Academy of Engineering,...
The Inner Game of Golf
How to improve your game and discover your true potential by increasing your concentration, willpower and confidence Every golfer, whether amateur or pro, who has ever picked up a club knows what it's like to get the yips - that feeling when you inexplicably lose control of your shot, and become overwhelmed by self-doubt, tension, fear of failure and anxiety. With a new introduction from golf performance pro Peter Hudson, the multi-million bestselling The Inner Game of Golf resolves this mental interference. It is not a book about how to play golf; it is a book about how to learn golf, and its lessons can be applied to any sport. Putting aside the mechanics of golfing technique and laborious...
