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Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases
This book describes the author’s work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole–imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced i...
Policy Entrepreneurship and Elections in Japan
Ozawa Ichirō is one of the most important figures in Japanese politics, having held the positions of Chief Secretary of the Liberal Democrat Party and, after defection from the LDP, President of the Democratic Party of Japan. Ozawa has distinctive ideas that set him apart from the average Japanese politician, he believes in the concept of the independence of the individual, as opposed to the importance of the group, and as a policy entrepreneur he has had a huge impact on political change not only advocating but precipitating institutional change in a key political area – the election system. Using extensive interview data from key players in the political arena, this book examines Ozawa'...
Healing Grounds
A powerful movement is happening in farming today—farmers are reconnecting with their roots to fight climate change. For one woman, that’s meant learning her tribe’s history to help bring back the buffalo. For another, it’s meant preserving forest purchased by her great-great-uncle, among the first wave of African Americans to buy land. Others are rejecting monoculture to grow corn, beans, and squash the way farmers in Mexico have done for centuries. Still others are rotating crops for the native cuisines of those who fled the “American wars” in Southeast Asia. In Healing Grounds, Liz Carlisle tells the stories of Indigenous, Black, Latinx, and Asian American farmers who are revi...
Parallel Inference Engine
This text describes the machine model designed to support parallel interface, the design of the Kleng language, the design and implementation of the parallel interface engine, the programming tools, the runtime system, and some evaluation results. The architecture of the PIE 64 is tuned specially to support parallel inference. The compiler and runtime systems proposed here are designed to reduce the overhead that inevitably incurrs when using fine granularity processing.
I Confess!
In the postwar decades, sexual revolutions – first women's suffrage, flappers, Prohibition, and Mae West; later Alfred Kinsey, Hugh Hefner, and the pill – altered the lifestyles and desires of generations. Since the 1990s, the internet and its cataclysmic cultural and social technological shifts have unleashed a third sexual revolution, crystallized in the acts and rituals of confession that are a staple of our twenty-first-century lives. In I Confess!, a collection of thirty original essays, leading international scholars such as Ken Plummer, Susanna Paasonen, Tom Roach, and Shohini Ghosh explore the ideas of confession and sexuality in moving image arts and media, mostly in the Global ...
Artificial Assemblies with Cooperative DNA Recognition
This book presents three types of synthetically cooperative DNA recognizing assemblies, in order to advance the development of programmable DNA-binding pyrrole–imidazole polyamides (PIPs). PIPs represent the best-characterized class of small molecule DNA binders that can be modified to bind with any predetermined DNA sequence and regulate gene expression patterns in a transgene-free and cost-effective manner. PIPs are characterized by their small molecular size, high binding affinity, programmability, sequence selectivity, and moderate cell permeability. In recent years, there have been numerous novel studies on the applications of these biological tools; this research is thoroughly review...
