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Artificial Assemblies with Cooperative DNA Recognition
This book presents three types of synthetically cooperative DNA recognizing assemblies, in order to advance the development of programmable DNA-binding pyrrole–imidazole polyamides (PIPs). PIPs represent the best-characterized class of small molecule DNA binders that can be modified to bind with any predetermined DNA sequence and regulate gene expression patterns in a transgene-free and cost-effective manner. PIPs are characterized by their small molecular size, high binding affinity, programmability, sequence selectivity, and moderate cell permeability. In recent years, there have been numerous novel studies on the applications of these biological tools; this research is thoroughly review...
Nucleic Acids in Medicinal Chemistry and Chemical Biology
Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nu...
Molecular Recognition of DNA Double Helix
In this book, the molecular recognition of DNA using small molecules is discussed, with a study of the photochemistry of BrU-labeled DNA. The purposes of the study were to develop small molecules for regenerative medicine, to develop a method to detect the recognition site of small molecules, and to detect the most important biological phenomena using the photochemistry of BrU-labeled DNA. The study began with the design and development of small molecules that can induce pluripotency genes. To deal with the important issue of cell permeability of the original compound, a new analogue of the original with improved gene expression was designed and synthesized. Using the photochemistry of BrU-labeled DNA, crucial biological phenomena such as cooperativity between transcription factors were detected. For the first time, the cooperativity was examined by excess electron transfer assay. DNA was also studied very carefully in order to understand the mechanism of the double-strand break in the UVA micro-irradiation technique. The mechanism of the double strand remained untouched. Nevertheless, the double-strand break mechanism was clearly demonstrated by Hoechst dye, as shown in this book.
Data and Applications Security and Privacy XXVIII
This book constitutes the refereed proceedings of the 28th IFIP WG 11.3 International Working Conference on Data and Applications Security and Privacy, DBSec 2014, held in Vienna, Austria, in July 2014. The 22 revised full papers and 4 short papers presented were carefully reviewed and selected from 63 submissions. The papers are organized in topical sections on access control, privacy, networked and mobile environments, data access, cloud databases, and private retrieval.
Proceedings of the IFIP TC 11 23rd International Information Security Conference
These proceedings contain the papers selected for presentation at the 23rd Inter- tional Information Security Conference (SEC 2008), co-located with IFIP World Computer Congress (WCC 2008), September 8–10, 2008 in Milan, Italy. In - sponse to the call for papers, 143 papers were submitted to the conference. All - pers were evaluated on the basis of their signi?cance, novelty,and technical quality, and reviewed by at least three members of the program committee. Reviewing was blind meaning that the authors were not told which committee members reviewed which papers. The program committee meeting was held electronically, holding - tensive discussion over a period of three weeks. Of the paper...
Contemporary New Confucianism II
As the second volume of a two-volume seminal work on contemporary New Confucianism in China, this book focuses on six leading thinkers of this intellectual movement in the 20th century. Contemporary New Confucianism refers to the Confucianism or Confucian thought that has emerged in China since the 1920s, which aims to revive the spirituality of Confucianism in a changing society. This volume introduces the philosophical thought of Zhang Junmai, Feng Youlan, He Lin, Fang Dongmei, Tang Junyi, and Mou Zongsan, including Zhang's political philosophy and comparative philosophy, Feng's transformation of Chinese philosophy, He's idea of culture and "spirit-only idealism," Fang's comparative philosophy, Tang's idea of moral self and theory of human spiritual realms, and Mou's new ontology for Confucianism. It analyzes their divergences and the contemporary relevance of their thought in terms of revisiting and transforming traditional Chinese philosophy and reconciling Chinese and Western traditions. This title will appeal to scholars and students of modern and contemporary Confucianism, intellectual history, philosophy and thought of contemporary China, and comparative philosophy.
Data and Applications Security and Privacy XXVII
This book constitutes the refereed proceedings of the 27th IFIP WG 11.3 International Conference on Data and Applications Security and Privacy, DBSec 2013, held in Newark, NJ, USA in July 2013. The 16 revised full and 6 short papers presented were carefully reviewed and selected from 45 submissions. The papers are organized in topical sections on privacy, access control, cloud computing, data outsourcing, and mobile computing.
Data and Applications Security and Privacy XXVI
This book constitutes the refereed proceedings of the 26th IFIP WG 11.3 International Conference on Data and Applications Security and Privacy, DBSec 2012, held in Paris, France in July 2012. The 17 revised full and 15 short papers presented together with 1 invited paper were carefully reviewed and selected from 49 submissions. The papers are organized in topical sections on access control, confidentiality and privacy, smart cards security, privacy-preserving technologies, data management, intrusion and malware, probabilistic attacks and protection, and cloud computing.
