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Concomitant Epigenetic Targeting of LSD1 and HDAC Synergistically Induces Mitochondrial Apoptosis in Rhabdomyosarcoma Cells
Abstract: The lysine-specific demethylase 1 (LSD1) is overexpressed in several cancers including rhabdomyosarcoma (RMS). However, little is yet known about whether or not LSD1 may serve as therapeutic target in RMS. We therefore investigated the potential of LSD1 inhibitors alone or in combination with other epigenetic modifiers such as histone deacetylase (HDAC) inhibitors. Here, we identify a synergistic interaction of LSD1 inhibitors (i.e., GSK690, Ex917) and HDAC inhibitors (i.e., JNJ-26481585, SAHA) to induce cell death in RMS cells. By comparison, LSD1 inhibitors as single agents exhibit little cytotoxicity against RMS cells. Mechanistically, GSK690 acts in concert with JNJ-26481585 to...
Next-generation Sequencing Reveals a Novel Role of Lysine-specific Demethylase 1 in Adhesion of Rhabdomyosarcoma Cells
Abstract: Lysine-specific demethylase 1 (LSD1), a histone lysine demethylase with the main specificity for H3K4me2, has been shown to be overexpressed in rhabdomyosarcoma (RMS) tumor samples. However, its role in RMS biology is not yet well understood. Here, we identified a new role of LSD1 in regulating adhesion of RMS cells. Genetic knockdown of LSD1 profoundly suppressed clonogenic growth in a panel of RMS cell lines, whereas LSD1 proved to be largely dispensable for regulating cell death and short-term survival. Combined RNA and ChIP-sequencing performed to analyze RNA expression and histone methylation at promoter regions revealed a gene set enrichment for adhesion-associated terms upon...
Tina
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Dubrova_ki simfonijski orkestar 1971. 1979.
Ova knjiga ne govori o teoriji glazbe, niti o tome kako ravnati operom, a kako simfonijskim orkestrom; kako dirigirati Bacha, a kako Brahmsa; ve_ o zivim drustvenim zbivanjima, o vaznosti djelovanja na me_unarodnoj glazbenoj sceni i izuzetnim uspjesima simfonijskog orkestra Grada Dubrovnika.
American Antebellum Fiddling
This unique volume is the only book solely about antebellum American fiddling. It includes more than 250 easy-to-read and clearly notated fiddle tunes alongside biographies of fiddlers and careful analysis of their personal tune collections. The reader learns what the tunes of the day were, what the fiddlers’ lives were like, and as much as can be discovered about how fiddling sounded then. Personal histories and tunes’ biographies offer an accessible window on a fascinating period, on decades of growth and change, and on rich cultural history made audible. In the decades before the Civil War, American fiddling thrived mostly in oral tradition, but some fiddlers also wrote down versions ...
Clavier
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The Piano Quarterly
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