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Chromatin and Epigenetics
Genomics has gathered broad public attention since Lamarck put forward his top-down hypothesis of 'motivated change' in 1809 in his famous book "Philosophie Zoologique" and even more so since Darwin published his famous bottom-up theory of natural selection in "The Origin of Species" in 1859. The public awareness culminated in the much anticipated race to decipher the sequence of the human genome in 2002. Over all those years, it has become apparent that genomic DNA is compacted into chromatin with a dedicated 3D higher-order organization and dynamics, and that on each structural level epigenetic modifications exist. The book "Chromatin and Epigenetics" addresses current issues in the fields...
Approaching the Three-dimensional Organization of the Human Genome
To approach the still largely unknown sequential and three-dimensional organization of the human cell nucleus, the structural-, scaling- and dynamic properties of interphase chromosomes and cell nuclei were simulated on the 30 nm chromatin fiber level with Monte Carlo, Brownian Dynamics and parallel computing methods. Differences between used models explain various experimental conditions, favouring a Multi-Loop-Subcompartment model with 63-126 kbp loops aggregated to possibly rosettes connected by 63-126 kbp linkers, and predict correctly the transport of molecules by moderately obstructed diffusion excluding the Interchromosomal Domain hypothesis. Correlation analyses of completely sequenc...
Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine
This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are nec...
Synthetic Genomics
The current advances in sequencing, data mining, DNA synthesis, cloning, in silico modeling, and genome editing have opened a new field of research known as Synthetic Genomics. The main goal of this emerging area is to engineer entire synthetic genomes from scratch using pre-designed building blocks obtained by chemical synthesis and rational design. This has opened the possibility to further improve our understanding of genome fundamentals by considering the effect of the whole biological system on biological function. Moreover, the construction of non-natural biological systems has allowed us to explore novel biological functions so far not discovered in nature. This book summarizes the current state of Synthetic Genomics, providing relevant examples in this emerging field.
Economics of Grids, Clouds, Systems, and Services
This book constitutes the refereed proceedings of the 13th International Conference on Economics of Grids, Clouds, Systems, and Services, GECON 2016, held in Athens. Greece, in September 2016. The 11 revised full papers and 11 short papers presented were carefully reviewed and selected from 38 submissions. This volume has been structured following the seven sessions that comprised the conference program (three of which are work-in-progress sessions): Session 1: Business Models Session 2: Work in Progress on Quality of Services and Service Level Agreements Session 3: Work in Progress on Cloud Economics Session 4: Energy Consumption Session 5: Resource Allocation Session 6: Work in Progress on Resource Allocation Session 7: Cloud Applications
Ecological Economics
An introduction to ecological economics, an emerging discipline combining economics, natural science, and philosophy in the study of the interaction between humans and the natural world. The nine contributors collate their individual knowledge in these traditionally isolated fields producing essays that speak to the roles of science and ethics, evolution in biology, physics, and economics, the relationship between a philosophical experience and an environmental reality, and test cases in linking ecology and economy in the chemical industry. Annotation copyright by Book News, Inc., Portland, OR
Gene Expression and Phenotypic Traits
Gene expression is the most fundamental level at which genotype gives rise to phenotype, which is an obvious, observable, and measurable trait. Phenotype is dependent on genetic makeup of the organism and influenced by environmental conditions. This book explores the significance, mechanism, function, characteristic, determination, and application of gene expression and phenotypic traits.
Performance at the Limit
Studies the case of Formula 1® to show how businesses can achieve optimal performance in competitive and dynamic environments.
