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Stem Cell Biology and Gene Therapy
STEM CELL BIOLOGY AND GENE THERAPY Edited by Peter J. Quesenberry, Gary S. Stein, Bernard Forget, and Sherman Weissman Advances in molecular genetics and recombinant DNA technology have ushered in a new era in medical therapeutic research. New insights into the molecular basis of human disease and the role played by biological regulatory mechanisms have precipitated tremendous drug development efforts backed by intensive research into human gene therapy worldwide. Stem Cell Biology and Gene Therapy is the first book to thoroughly cover major advances in the field and their applications to novel molecular therapies. This self-contained volume integrates biological and clinical components of s...
Energy Harvesting Systems
Kinetic energy harvesting converts movement or vibrations into electrical energy, enables battery free operation of wireless sensors and autonomous devices and facilitates their placement in locations where replacing a battery is not feasible or attractive. This book provides an introduction to operating principles and design methods of modern kinetic energy harvesting systems and explains the implications of harvested power on autonomous electronic systems design. It describes power conditioning circuits that maximize available energy and electronic systems design strategies that minimize power consumption and enable operation. The principles discussed in the book will be supported by real case studies such as battery-less monitoring sensors at water waste processing plants, embedded battery-less sensors in automotive electronics and sensor-networks built with ultra-low power wireless nodes suitable for battery-less applications.
Blood Cell Biochemistry
Since the first concepts of gene therapy were formulated, the hemopoietic system has been considered the most natural first target tissue for genetic manipulation. The reasons for this include the fact that a very large number of inherited disorders (including some of the most common disorders, such as the hemoglobinopathies) are disorders of the hemopoietic system, and the large amount of experience in hematopoietic transplantation biology. The consequence of this resulted in the first clinical trial of gene therapy in 1989, where two children suffering from severe combined immune deficiency (ADA-SCID) were transplanted with T-cells express ing adenosine deaminase (the defective enzyme in p...
Gene Therapy
K. Sikora Gene therapy is one of the fastest developing areas in modern medical research. Transcending the classical preclinical and clinical disciplines, it is likely to have far reaching consequences in the practice of medicine, as we enter the next millennium. Currently, there are over 200 seperate active clinical trials with over 2,500 patients entered. These studies involve over 20 countries and include patients with a wide range of diseases, including cancer, HIV infection; cystic fibrosis (CF), haemophilia, diabetes, immune deficiencies, metabolic disorders, ischaemic heart disease and arthritis. Gene therapy can be defined as the deliberate transfer of DNA for therapeutic purposes. T...
Nanosols And Textiles
The book provides a short introduction to the sol-gel process, principles in modification of the sols and technical details of the application on textiles, covering in particular the chemical content of the topic. New properties of textiles gained from nanosols are summarized and explained in a broad range, focusing on the mechanical and thermal stability, repellent properties, optical properties, antistatic coatings and bioactive coatings. An active discussion is held on the bioactive modifications, because this wide and interesting field offers a high potential for many new applications, e.g. in medicine. Besides basic research, this book will also provide examples on the transition of academic research to customer products.
Silicon-Containing Polymers
Silicon-containing Polymers reflects the growing interest worldwide in this developing field. Silicon polymers are now finding use as moulding materials, rubbers, ceramic precursors, in lithography and reprography as photosensitive materials, as conducting polymers, and in a host of other applications. This book presents up-to-date research from all over the world. It brings together research from the forefront of a multidisciplinary subject, covering the synthesis, modification, characterization, properties and applications of polysiloxanes, polysilylenes, polysilazanes and organosilicate derivatives. Silicon-containing Polymers will be of interest to researchers and postgraduates in any area of materials science, as well as some areas of inorganic chemistry.
