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Neurobiology of Opioids
Dedicated to Professor Albert Herz, a leading investigator in opioid research, this book provides comprehensive information on the biology of exogenous and endogenous opioids. Contributions by experts in the field discuss recent advances and provide systematic, up-to-date reviews of the physiology and pharmacology of opioids, as well as on the cellular and molecular mechanisms underlying opioid actions. In recognition of the diverse methodologies now available to researchers, each chapter details the approaches used to address a specific issue and provides an in-depth analysis of the data obtained by these various experimental approaches. The clinical relevance of recent findings, as well as future directions, in opioid research are also discussed. This volume thus represents a timely and invaluable sourcebook for researchers, clinicians, and students interested in opioids and peptidergic systems.
Opiate Receptors and Antagonists
Comprehensive and authoritative, Opioid Receptors and Antagonists: From Bench to Clinic offers neuroscientists, pharmacologists and interested clinicians a unique survey of the extensive and diverse research efforts currently employed with opioid antagonists to develop novel innovative drug therapies. Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes Highlights differences and similarities between the opioid pharmacology of animals and human Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications
Molecular Biology of Drug Addiction
A comprehensive multidisciplinary review of the most relevant molecular, genetic, and behavioral approaches used to investigate the neurobiological basis of drug addiction. The authors explore the latest findings on opioid, psychostimulant, cannabinoid, alcohol, and nicotine addiction, provide fresh insights into the genetic basis of drug addiction and the new therapeutic perspectives these have opened. They describe the technology available to generate conditional knockout mice and show how these mice can reveal the molecular basis of opioid, psychostimulant, and cannabinoid addiction. They also review the different behavioral models available to evaluate the rewarding effects of drugs and analyze the genes involved in alcohol dependence.
Neuropsychopharmacology
Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of all neuropsychiatric disorders. Nine sections focus on specific groups of disorders, covering clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
Addiction
Addiction focuses on the emergence, nature, and persistence of addictive behavior, as well as the efforts of addicts to overcome their condition. Do addicts act of their own free will, or are they driven by forces beyond their control? Do structured treatment programs offer more hope for recovery? What causes relapses to occur? Recent scholarship has focused attention on the voluntary aspects of addiction, particularly the role played by choice. Addiction draws upon this new research and the investigations of economists, psychiatrists, philosophers, neuropharmacologists, historians, and sociologists to offer an important new approach to our understanding of addictive behavior. The notion tha...
Advancing from the Ventral Striatum to the Extended Amygdala
The ventral striatopallidal and magnocellular systems emerged as organizing principles of the basal forebrain during the 1970s and 1980s. The concept of the extended amygdala, while still controversial, is beginning to guide the thinking of scientists in the 1990s who are investigating the role of the basal forebrain in motivated behaviours and their dysfunction. This volume explores the anatomy and function of the basal forebrain systems in neuropsychiatric and addictive behaviour.
