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This collection of Heinz König’s publications connects to his book of 1997 “Measure and Integration” and presents significant developments in the subject from then up to the present day. The result is a consistent new version of measure theory, including selected applications. The basic step is the introduction of the inner • (bullet) and outer • (bullet) premeasures and their extension to unique maximal measures. New “envelopes” for the initial set function (to replace the traditional Carathéodory outer measures) have been created, which lead to much simpler and more explicit treatment. In view of these new concepts, the main results are unmatched in scope and plainness, as ...
Driven in part by the development of genomics, proteomics, and bioinformatics as new disciplines, there has been a tremendous resurgence of interest in physical methods to investigate macromolecular structure and function in the context of living cells. This volume in Methods in Cell Biology is devoted to biophysical techniques in vitro and their applications to cellular biology. Biophysical Tools for Biologists covers methods-oriented chapters on fundamental as well as cutting-edge techniques in molecular and cellular biophysics. This book is directed toward the broad audience of cell biologists, biophysicists, pharmacologists, and molecular biologists who employ classical and modern biophysical technologies or wish to expand their expertise to include such approaches. It will also interest the biomedical and biotechnology communities for biophysical characterization of drug formulations prior to FDA approval. - Describes techniques in the context of important biological problems - Delineates critical steps and potential pitfalls for each method - Includes full-color plates to illustrate techniques
Linear systems can be regarded as a causal shift-invariant operator on a Hilbert space of signals, and by doing so this book presents an introduction to the common ground between operator theory and linear systems theory. The book therefore includes material on pure mathematical topics such as Hardy spaces, closed operators, the gap metric, semigroups, shift-invariant subspaces, the commutant lifting theorem and almost-periodic functions, which would be entirely suitable for a course in functional analysis; at the same time, the book includes applications to partial differential equations, to the stability and stabilization of linear systems, to power signal spaces (including some recent material not previously available in books), and to delay systems, treated from an input/output point of view. Suitable for students of analysis, this book also acts as an introduction to a mathematical approach to systems and control for graduate students in departments of applied mathematics or engineering.
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Amyloid-forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease-specific lesions in vivo. Substantial evidence suggests these lesions are the end state of aberrant protein folding whereas the actual disease-causing culprits likely are soluble, non-fibrillar assemblies preceding the aggregates. The non-fibrillar protein assemblies range from small, low-order oligomers to spherical, annular, and protofibrillar species. Oligomeric species are believed to media...
Non-Additive Measure and Integral is the first systematic approach to the subject. Much of the additive theory (convergence theorems, Lebesgue spaces, representation theorems) is generalized, at least for submodular measures which are characterized by having a subadditive integral. The theory is of interest for applications to economic decision theory (decisions under risk and uncertainty), to statistics (including belief functions, fuzzy measures) to cooperative game theory, artificial intelligence, insurance, etc. Non-Additive Measure and Integral collects the results of scattered and often isolated approaches to non-additive measures and their integrals which originate in pure mathematics...
Classical in its approach, this textbook is thoughtfully designed and composed in two parts. Part I is meant for a one-semester beginning graduate course in measure theory, proposing an “abstract” approach to measure and integration, where the classical concrete cases of Lebesgue measure and Lebesgue integral are presented as an important particular case of general theory. Part II of the text is more advanced and is addressed to a more experienced reader. The material is designed to cover another one-semester graduate course subsequent to a first course, dealing with measure and integration in topological spaces. The final section of each chapter in Part I presents problems that are inte...
This book presents the results of broad interdisciplinary effort to study proteins in physical and evolutionary prospective. Among authors are physicists, computational chemists, crystallographers and evolutionary biologists. New experimental and theoretical developments ''from molecules to cells'' are presented providing a broad picture of modern biophysical chemistry