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Nonlinear Dynamics in Geosciences
This work comprises the proceedings of a conference held last year in Rhodes, Greece, to assess developments during the last 20 years in the field of nonlinear dynamics in geosciences. The volume has its own authority as part of the Aegean Conferences cycle, but it also brings together the most up-to-date research from the atmospheric sciences, hydrology, geology, and other areas of geosciences, and discusses the advances made and the future directions of nonlinear dynamics.
Microdosimetry
Experimental microdosimetry deals with the measurement of charged particle energy deposition in tissue equivalent volumes, ranging in size from nanometres to micrometres. Microdosimetry is employed to improve our understanding of the relationship between radiation energy deposition, the resulting biological effects, and the appropriate quantities to be used in characterizing and quantifying radiation quality. Although many reviews and contributions to the field have been published over the past fifty years, this new book is the first to provide a single, up to date, and easily accessible account of experimental microdosimetry. This book is designed to be used in medical, radiation, and healt...
Risk and Protective Factors in Schizophrenia
The present volume contains the lectures of the symposium on 'Risk and Protective Factors in Schizophrenia - towards a conceptual Model of the Disease Process', which was held at the International Science Forum of the University of Heidelberg on October, 2001. The topics of the program were 'Genetic risk factors and gene environment interaction', 'Psychotic and negative symptoms in the general population as risk-factors', 'Etiological risk factors in embryonal life, childhood and adolescence', 'Prepsychotic prodromi and stage models of the development of psychosis', 'Brain development, structural and functional morphology of the early course', 'Urban versus rural life, migration and social c...
Improving the Utility and Translation of Animal Models for Nervous System Disorders
Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in ...
Thermodynamics and Kinetics of Drug Binding
This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.
Working-Class Literature(s)
"The aim of this collection is to make possible the forging of a more robust, politically useful, and theoretically elaborate understanding of working-class literature(s). These essays map a substantial terrain: the history of working-class literature(s) in Russia/The Soviet Union, The USA, Finland, Sweden, The UK, and Mexico. Together they give a complex and comparative - albeit far from comprehensive - picture of working-class literature(s) from an international perspective, without losing sight of national specificities. By capturing a wide range of definitions and literatures, this collection gives a broad and rich picture of the many-facetted phenomenon of working-class literature(s), d...
World Congress on Communication For Development
"Communication for Development is a multidisciplinary area of study and work that is based on two-way models of communication, going beyond diffusion and dissemination of information. Its functions range from engaging stakeholders in problem analysis and risk assessment to supporting behavior and social change. The experiences recounted here are drawn from the various sessions of the Congress and emphasize the value of using Communication for Development to engage stakeholders in a professional and systematic manner for more effective and sustainable project design and implementation."--BOOK JACKET.
