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Neuroinflammation — From Bench to Bedside
Recent work has implicated inflammatory processes in the pathophysiology of a variety of neurodegenerative diseases such as Alzheimer's disease, stroke and multiple sclerosis. In this book leading experts in the field discuss molecular, in vivo and clinical aspects of neuroinflammation. It is hoped, with the wealth of research being conductied in this area, that novel therapeutic targets will be identified which will allow successful therapeutic intervention in a variety of neurodegenerative diseases.
Regenerative and Cell Therapy
This book gives an updated review of the state of the art in regenerative cell therapy in the fields of cardiology, hematology, pediatrics, neurology, orthopedics and infectious diseases. The book emphasizes clinical advances as proof of concept in cell therapy based on the revolutionizing observation that regeneration can occur throughout the body even in highly differentiated organs like the heart and the neuronal system. It provides examples of breakthroughs in the clinical implementation of adult stem cell therapy.
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expectedto provide the basis for entirely new future therapies.
Drug Transporters
Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field. The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical too...
The Routledge Handbook of Human-Animal Relations in the Byzantine World
Animals have recently become recognized as significant agents of history as part of the ‘animal turn’ in historical studies. Animals in Byzantium were human companions, a source of entertainment and food – it is small wonder that they made their way into literature and the visual arts. Moreover, humans defined themselves and their activities by referring to non-human animals, either by anthropomorphizing animals (as in the case of the Cat-Mice War) or by animalizing humans and their (un)wanted behaviours. The Routledge Handbook of Human-Animal Relations in the Byzantine World offers an in-depth survey of the relationships between humans and non-human animals in the Byzantine Empire. Th...
Thesaurus Linguae Graecae
The thesaurus of the Greek language (1972-2022) : a brief history of the project -- Classifications and conventions : the Canon standard -- Acknowledgments -- Codes and sigla -- Bibliographic abbreviations -- The Canon of Greek authors and works -- Index of TLG author numbers.
The Handbook of Medicinal Chemistry
Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry has been revised and brought up to date to cover the past, present and future of the entire drug development process.
The Histone Code and Beyond
Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
Neuroinflammation in Stroke
The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy.
Molecular Imaging
The continuous progress in the understanding of molecular processes of disease formation and progression attributes an increasing importance to biomedical molecular imaging methods. The purpose of this workshop was to discuss and overview multiple applications and emerging technologies in the area of diagnostic imaging including its fundamental capabilities in preclinical research, the opportunities for medical care, and the options involving therapeutic concepts. The book provides the reader with state-of-the-art information on the different aspects of diagnostic imaging, illuminating new developments in molecular biology, imaging agents and molecular probe design, and therapeutic techniques.
