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This thesis is about a new model querying and transformation approach called FunnyQT which is realized as a set of APIs and embedded domain-specific languages (DSLs) in the JVM-based functional Lisp-dialect Clojure. Founded on a powerful model management API, FunnyQT provides querying services such as comprehensions, quantified expressions, regular path expressions, logic-based, relational model querying, and pattern matching. On the transformation side, it supports the definition of unidirectional model-to-model transformations, of in-place transformations, it supports defining bidirectional transformations, and it supports a new kind of co-evolution transformations that allow for evolving ...
"This resource will educate students and pharmacists on traditional drug information topics while providing an extensive background on more recent practice areas. This is a user-friendly text with multiple examples that can be used in education and training, as well as clinical practice. Each chapter includes learning objectives, key terms, example
Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation,...
A biosensor is a detecting device that combines a transducer with a biologically sensitive and selective component. Biosensors can measure compounds present in the environment, chemical processes, food and human body at low cost if compared with traditional analytical techniques. This book covers a wide range of aspects and issues related to biosensor technology, bringing together researchers from 19 different countries. The book consists of 27 chapters written by 106 authors and divided in three sections: Biosensors Technology and Materials, Biosensors for Health and Biosensors for Environment and Biosecurity.
The development of new pharmaceutical products and behavioral interventions aimed at improving people's health, as well as research that assesses the efficacy and cost-effectiveness of public policies, such as policies designed to improve children's education or reduce poverty, depends on research conducted with human participants. It is imperative that research with human subjects is conducted in accordance with sound ethical principles and regulatory requirements. Featuring 45 original essays by leading research ethicists, The Oxford Handbook of Research Ethics offers a critical overview of the ethics of human subjects research within multiple disciplines and fields, including biomedicine, public health, psychiatry, sociology, political science, and public policy.
This book constitutes the refereed proceedings of the 16th International Workshop on Communication Technologies for Vehicles, Nets4Cars/Nets4Trains/Nets4Aircraft 2021, held in Madrid, Spain, in November 2021. The 6 full and 2 short papers were carefully reviewed and selected from numerous submissions. The selected papers present original research results in areas related to the physical layer, communication protocols and standards, mobility and traffic models, experimental and field operational testing, and performance analysis
Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics features contributions from leading international experts in all ar...
Pharmacogenomics is comprehensive textbook detailing how genetic makeup affects a body's response to drugs.