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The NIH Catalyst
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Smart Services Summit
This book presents up-to-date descriptions of smart services innovations in industry, supported by new scientific approaches. It summarizes the outcomes of the fourth Smart Services Summit, held in Zurich in October 2022, which primarily focused on how smart services can promote sustainability. As smart services accelerate, new technologies can be leveraged to create new value propositions and business models that deliver tangible sustainability outcomes. This book addresses social, economic and environmental aspects of sustainability in connection with new technologies. It includes contributions on how the quality and value of services are affected by digital technologies, how collaboration affects shared value creation, and how organizations can be enabled to drive digital value creation. Given its scope, the book represents an indispensable guide for practitioners and advanced students alike.
Jak-Stat Signaling : From Basics to Disease
JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.
Proceedings
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Responsible Librarianship
These papers examine library policies and organizational structures in light of the literature of ergonomics, high reliability organizations, joint cognitive systems and integrational linguistics. Bade argues that many policies and structures have been designed and implemented on the basis of assumptions about technical possibilities, ignoring entirely the political dimensions of local determination of goals and purposes as well as the lessons from ergonomics, such as the recognition that people are the primary agents of reliability in all technical systems. Because libraries are understood to be loci of human interaction and communication rather than purely technical systems at the disposal of an abstract user, Bade insists on looking at problems of meaning and communication in the construction and use of the library catalog. Looking at various policies for metadata creation and the results of those policies forces the question: is there a responsible human being behind the library web site and catalog, or have we abandoned the responsibilities of thinking and judgment in favor of procedures, algorithms and machines?
Encyclopedia of Automotive Engineering
Erstmals eine umfassende und einheitliche Wissensbasis und Grundlage für weiterführende Studien und Forschung im Bereich der Automobiltechnik. Die Encyclopedia of Automotive Engineering ist die erste umfassende und einheitliche Wissensbasis dieses Fachgebiets und legt den Grundstein für weitere Studien und tiefgreifende Forschung. Weitreichende Querverweise und Suchfunktionen ermöglichen erstmals den zentralen Zugriff auf Detailinformationen zu bewährten Branchenstandards und -verfahren. Zusammenhängende Konzepte und Techniken aus Spezialbereichen lassen sich so einfacher verstehen. Neben traditionellen Themen des Fachgebiets beschäftigt sich diese Enzyklopädie auch mit "grünen" Tec...
Lost from the Ottawa
The story of a Native boy born in a mental hospital 1945, and adopted into a white world. Details his epic journey around the world, through drugs and prison and being the FBI's most-wanted fugitive as he searched for family and tribe.
Methods in Mammary Gland Biology and Breast Cancer Research
approaches to the experimental problems that still face us in understanding this most fascinating of organs. Too many people contributed to the completion of this volume to allow acknowledg ment of all the individual efforts, but we particularly thank the reviewers whose input into the editorial process was invaluable and the authors of these chapters who revised their text, sometimes more than once, to bring it to the high standards set by the Editors. The Com mittee gratefully acknowledges the support ofVysis, Inc. , in the publication of a color figure in Chapter 19, by S. Weber-Hall and Trevor Dale. Finally, we wish to express our heartfelt appreciation to Margot Ip and Bonnie Asch, who ...
The Corporates Strike Back
65% of global CEOs are concerned about losing the innovation race against disruptive start-ups. The supposed solution: copying their methods. But as corporations are not start-ups, this is a fatal mistake. Most ideas never reach successful implementation, and innovation becomes frustration. So how does a solution look like that enables large firms to systematically leverage their existing strength and thus win the innovation race sustainably? The answer is the 5C process for efficient innovation. This book closes a gap in the practice-oriented innovation literature - and brings the desire for innovation back to established companies. The road to successful innovation management is long - this book is the shortcut. Thomas Weiler, VP Innovation Portfolio & Strategic Programs, Deutsche Telekom An overdue update on traditional R&D processes for the 21st century. Uwe Wagner, CTO, Schaeffler Anyone who has ever experienced the methodology described here in practice will hide the book from the competition! Dr. Carsten Stöcker, World Economic Forum, Global Future Council-Member
