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This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including: host-pathogen interactions causal relationships between genes and the environment the effects of environmental chemicals on gene expression DNA methylation The book also covers the analysis and provides models for understanding the epigenetics-pathology connection. This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.
The adverse effects of climate change are now apparent and present urgent and complex challenges to human health and health systems globally. There is an imperative for quick action on many fronts: to recognize and respond to climate-health threats; prevent climate change at its source by reducing greenhouse gas emissions; support “greener” systems throughout the economy, including healthcare; understand the health co-benefits of adaptation and mitigation; and communicate effectively about these issues. Climate change is intertwined with historical and structural inequities and effective solutions must actively improve health equity. To meaningfully address these deep and interconnected ...
Far from teleological historiography, the pan-European perspective on Early Modern drama offered in this volume provides answers to why, how, where and when the given phenomena of theatre appear in history. Using theories of circulation and other concepts of exchange, transfer and movement, the authors analyze the development and differentiation of European secular and religious drama, within the disciplinary framework of comparative literature and the history of literature and concepts. Within this frame, aspects of major interest are the relationship between tradition and innovation, the status of genre, the proportion of autonomous and heteronomous creational dispositions within the artef...
Proposing an original and important re-conceptualization of Italian Renaissance drama, Kristin Phillips-Court here explores how the intertextuality of major works of Italian dramatic literature is not only poetic but also figurative. She argues that not only did the painterly gaze, so prevalent in fifteenth- and sixteenth-century devotional art, portraiture, and visual allegory, inform humanistic theories, practices and themes, it also led prominent Italian intellectuals to write visually evocative works of dramatic literature whose topical plots and structures provide only a fraction of their cultural significance. Through a combination of interpretive literary criticism, art historical ana...
This book studies the uses of orality in Italian society, across all classes, from the fifteenth to the seventeenth century, with an emphasis on the interrelationships between oral communication and the written word. The Introduction provides an overview of the topic as a whole and links the chapters together. Part 1 concerns public life in the states of northern, central, and southern Italy. The chapters examine a range of performances that used the spoken word or song: concerted shouts that expressed the feelings of the lower classes and were then recorded in writing; the proclamation of state policy by town criers; songs that gave news of executions; the exercise of power relations in soc...
This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice. The book includes chapters on these topics: • Gene expression in colon cancer tissue • Epigenetics in human acute kidney injury • Embryologically relevant candidate genes in MRKH patients • DNA methylation in common skeletal disorders • Causal relationships in genomics • Predicting severe asthma exacerbations in children • Epigenetic understanding of gene-environment interactions in psychiatric disorders
Focusing on actresses in France during the early modern period, Virginia Scott examines how the stereotype of the actress has been constructed. The study then moves beyond that stereotype to detail the reality of the personal and artistic lives of women on the French stage, from the almost unknown Marie Ferré - who signed a contract for 12 livres a year in 1545 to perform the 'antiquailles de Rome or other histories, moralities, farces, and acrobatics' in the provinces - to the queens of the eighteenth-century Paris stage, whose 'adventures' have overshadowed their artistic triumphs. The book also investigates the ways in which actresses made invaluable contributions to the development of the French theatre in the seventeenth and eighteenth centuries, and looks at the 'afterlives' of such women as Armande Béjart, Marquise Du Parc, Charlotte Desmares, Adrienne Lecouvreur, and Hippolyte Clairon in biographies, plays, and films.
Dreaming with Open Eyes examines visual symbolism in late seventeenth-century Italian opera, contextualizing the genre amid the broad ocularcentric debates emerging at the crossroads of the early modern period and the Enlightenment. Ayana O. Smith reevaluates significant aspects of the Arcadian reform aesthetic and establishes a historically informed method of opera criticism for modern scholars and interpreters. Unfolding in a narrative fashion, the text explores facets of the philosophical and literary background and concludes with close readings of text and music, using visual symbolism to create readings of gender and character in two operas: Alessandro Scarlatti's La Statira (Rome, 1690), and Carlo Francesco Pollarolo's La forza della virtù (Venice, 1693). Smith’s interdisciplinary approach enhances our modern perception of this rich and underexplored repertory, and will appeal to students and scholars not only of opera, but also of literature, philosophy, and visual and intellectual cultures.
Renaissance Drama, an annual interdisciplinary publication, is devoted to drama and performance as a central feature of Renaissance culture. The essays in each volume explore traditional canons of drama, the significance of performance (broadly construed) to early modern culture, and the impact of new forms of interpretation on the study of Renaissance plays, theater, and performance. This special issue of Renaissance Drama on "Italy in the Drama of Europe" primarily builds on the groundwork laid by Louise George Clubb, who showed that Italian drama was made in such a way as to facilitate its absorption and transformation into other traditions, even when it was not explicitly cited or referenced. "Italy in the Drama of Europe" takes up the reverberations of early modern Italian drama in the theaters of Spain, England, and France and in writings in Italian, English, Spanish, French, Hebrew, Latin, and German. Its scope is an example of the continuing force of and interest in one of the most rewarding, wide-ranging, and productive early modern aesthetic modes, and a tribute to the scholarship of Louise George Clubb, who, among others, recalled our attention to it.
Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction: Women, Rhetoric, and Drama in Early Modern Italy -- PART I: Women as Protagonists in Male-Authored Drama: Comedy and tragedy -- 1 Fathers, Daughters, Crossdressing, and Names: Women, Rhetoric, and Education in Commedia Erudita -- Coda: "Margherita Costa's Li buffoni (1641): The First (Extant) Female-Authored Scripted Comedy"--2 Fashioning a Genealogy: The Rhetoric of Friendship and Female Virtue in Italian Renaissance tragedy -- Coda: Valeria Miani's Celinda (1611) among Fin de Siècle Italian Tragedies -- PART II: Women as Authors/Women as Protagonists: Pastoral Tragicomedy -- 3 Women Writers and the Canon: Satyr Scenes and Female-Authored Pastoral Drama -- 4 Isabetta Coreglia's Dori (1634): Writing Pastoral Drama Against the Backdrop of the Male Canon and an Incipient Female-Authored Tradition -- 5 Isabetta Coreglia's Erindo il fido (1650) and Isabella Andreini's Mirtilla (1588): Using a Female-Authored Classic as Paradigm -- Appendix -- Bibliography -- Index