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Tumor immunotherapy has now shown its promise for many, its disappointments and failings for others. Going forward, brain tumor patients can both benefit and contribute. Tumor immunotherapy is steadily progressing. As experience accumulates, it is important to consider its generality. The reviews herein emphasize the brain’s place among other tumor sites. Two major topics are addressed. THE SITE: WHAT CAN WE EXPECT FROM IMMUNOTHERAPY WHEN THE TARGET IS IN THE BRAIN? Experience with immunotherapy for different targets in the brain, including tumor and also pathogens, is reviewed. Long-standing assumptions are confronted. The potential for beneficial responses is stressed. BRAIN TUMOR IMMUNOTHERAPY: WHAT HAVE WE LEARNED SO FAR? Clinical experience with brain tumor immunotherapy, from a variety of centers, is reviewed. Primary tumors, emphasizing glioblastoma, and brain metastases are each considered.
In recent years, biological cancer therapies, including immunotherapy, have moved from the bench to mainstream medical treatments of several types of cancer. The success of these treatments relies on innovative approaches to specifically interfere with molecular targets that are involved in the growth, progression, and spread of malignant cells, or to bypass the tumor evasion of the immune system utilizing the latest advances in cancer vaccine development, formulation, and delivery. This book presents an up-to-date overview of novel cancer biological and immunotherapeutic approaches, including cancer vaccines, mimetic vaccines, monoclonal antibodies, adoptive T-cell transfer, chimeric antigen receptor T- cells, tumor infiltrating lymphocytes, dendritic cells, natural killer cells, immune checkpoint inhibitors, laser ablation, and immune stimulating interstitial laser thermotherapy.
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The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 1-2696 presented on April 17-18, 2016, at the AACR Annual Meeting.
Sebagai korporasi, perseroan tebatas dapat bertindak dalam hukum untuk dan atas namanya sendiri. Direksi adalah organ perseroan yang bertugas dan bertanggung jawab penuh atas kepengurusan dan jalannya perseroan serta mewakili perseroan di luar maupun di dalam pengadilan. Karenanya tindakan direksi dianggap tindakan perseroan. Di dalam aktivitas korporasi di bidang hukum bisnis terdapat kemungkinan adanya perbuatan melawan hukum, yang bisa dimintakan pertanggungjawaban pribadi pengurusnya. Selain itu, bisa saja terdapat penyimpangan dalam bentuk melanggar ketentuan hukum pidana. Bagaimana kedudukan dan tanggung jawab direksi, baik selaku organ perseroan terbatas maupun selaku pribadi, dan perseroan terbatas itu sendiri, apabila ada perbuatan yang merugikan? Apakah perbuatan melawan hukum yang terjadi dalam ranah hukum pidana dapat dilakukan oleh perseroan terbatas dan dapat dimintakan pertanggungjawaban pidananya, dihubungkan dengan unsur kesalahan, serta perkembangan korporasi sebagai subjek hukum pidana. Buku persembahan penerbit Prenada Media Group.