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Chimeric Antigen Receptor T Cells
This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes.
Curso de Bioética e Biodireito
A obra aborda os principais questionamentos bioéticos advindos do avanço e do desenvolvimento das pesquisas biotecnológicas que alcançaram seu apogeu no final do século XX e início do século XXI. Valendo-se de uma visão multifacetada entre o direito e as ciências médicas, incluídas, entre outras, a nutrição, a psicologia, a antropologia e a sociologia, o livro apresenta grandes temas relativos à vida humana, sua dignidade e perpetuação, como o início da vida, os direitos do embrião, do nascituro e do anencéfalo; pesquisas com células tronco adultas e embrionárias, a clonagem humana, a experimentação cientifica em seres humanos, a identidade genética e familiar do ser humano. São estudadas diferentes questões à luz dos direitos humanos, dos direitos da personalidade e da liberdade religiosa. Faz também uma incursão nos principais temas de direito, valendo-se de dispositivos constitucionais, leis ordinárias e especiais, Resoluções do Conselho Federal de Medicina e Tratados Internacionais, num verdadeiro diálogo das fontes
Citrus Mites
Citrus pests are a serious issue for crop growers, causing problems in yield and economic losses. This title studies mites harmful to citrus plants from various citrus growing regions around the world. It addresses methods of removal from plants, describes symptoms of damage caused by pests and discusses methods of eradication and control.
Minicircle and Miniplasmid DNA Vectors
This first title on the topic provides complete coverage, including the molecular basis, production and possible biomedical applications. Written by the most prominent academic researchers in the field as well as by researchers at one of the world's leading companies in industrial production of minicircle DNA, this practical book is aimed at everyone who is directly or indirectly involved in the development of gene therapies.
Chimeric Antigen Receptor T-Cell Therapies for Cancer E-Book
From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. - Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. - Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. - Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. - Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.
Stem Cells and Cell Therapy
With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating and processing large numbers of cells to meet the need of clinical applications. With this in mind, our aim is to provide a book on the subject of stem cells and cell therapy f...
Sustainable Management of Arthropod Pests of Tomato
Sustainable Management of Arthropod Pests of Tomato provides insight into the proper and appropriate application of pesticides and the integration of alternative pest management methods. The basis of good crop management decisions is a better understanding of the crop ecosystem, including the pests, their natural enemies, and the crop itself. This book provides a global overview of the biology and management of key arthropod pests of tomatoes, including arthropod-vectored diseases. It includes information that places tomatoes in terms of global food production and food security, with each pest chapter including the predators and parasitoids that have specifically been found to have the great...
HIV and the Blood Supply
During the early years of the AIDS epidemic, thousands of Americans became infected with HIV through the nation's blood supply. Because little reliable information existed at the time AIDS first began showing up in hemophiliacs and in others who had received transfusions, experts disagreed about whether blood and blood products could transmit the disease. During this period of great uncertainty, decision-making regarding the blood supply became increasingly difficult and fraught with risk. This volume provides a balanced inquiry into the blood safety controversy, which involves private sexual practices, personal tragedy for the victims of HIV/AIDS, and public confidence in America's blood se...
Polymeric Gene Delivery Systems
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant development...
