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SNAIL1-mediated Downregulation of FOXA Proteins Facilitates the Inactivation of Transcriptional Enhancer Elements at Key Epithelial Genes in Colorectal Cancer Cells
Abstract: Phenotypic conversion of tumor cells through epithelial-mesenchymal transition (EMT) requires massive gene expression changes. How these are brought about is not clear. Here we examined the impact of the EMT master regulator SNAIL1 on the FOXA family of transcription factors which are distinguished by their particular competence to induce chromatin reorganization for the activation of transcriptional enhancer elements. We show that the expression of SNAIL1 and FOXA genes is anticorrelated in transcriptomes of colorectal tumors and cell lines. In cellular EMT models, ectopically expressed Snail1 directly represses FOXA1 and triggers downregulation of all FOXA family members, suggest...
Vivien - Primary Source Edition
This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book.
Vivian
Named Charles Irwin, Vivian was a juggler who was jailed after conceiving a fraudulant money making scheme with fellow entertainer Leo Kelvedon in Horsham in 1911. Performed in Queensland after he served his sentence. File contains newspaper articles.
Character Sketches of Romance, Fiction and the Drama
Reproduction of the original: Character Sketches of Romance, Fiction and the Drama by E. Cobham Brewer
