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Current Trends in Monoclonal Antibody Development and Manufacturing
Monoclonal antibodies represent one of the fastest growing areas of new drug development within the pharmaceutical industry. Several blockbuster products have been approved over the past several years including Rituxan, Remicade, Avastin, Humira, and Herceptin. In addition, over 300 new drugs are currently in clinical trials. With both large, established biotechnology companies and small start-ups involved in the development of this important class of molecules, monoclonal antibodies products will become increasingly prevalent over the next decade. Recently the regulatory review of monoclonal antibodies has been moved from Center for Biologics and Research to the Center for Drug Evaluation a...
Biomaterials Science
The revised edition of this renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science. It provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine. - Over 29,000 copies sold, this is the most comprehensive coverage of principles and applications of all classes of biomaterials: "the only such text that currently covers this area comprehensively" - Materials Today - Edited by four of the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials - Fully revised and expanded, key new topics include of tissue engineering, drug delivery systems, and new clinical applications, with new teaching and learning material throughout, case studies and a downloadable image bank
Frontiers in Biomedical Polymer Applications
The use of polymers in medicine has become a reality over the last 10 years. Scientists have been attempting to develop biomimetic materials to substitute for flawed or damaged natural systems. This new book presents the most up-to-date developments in the use of synthetic polymers as biomaterials Frontiers in Biomedical Polymer Applications is a compilation of the papers presented at the first International Meeting on the Frontiers of Medical Applications of Polymers. Held in St. Margarite, Italy, participants from countries throughout the world came to present their findings and to discuss future directions in this rapidly growing field. The text contains all 24 of the presentations and is well-illustrated with over 200 figures, tables, formulas and schemes.
Formulation, Characterization, and Stability of Protein Drugs
Leading scientists offer detailed profiles of ten protein drugs currently in development. The case histories of these important new compounds are described from the perspective of their formulation, characterization, and stability. This ready reference also features recent data and an abundance of previously unpublished information. The in-depth coverage includes a highly useful compendium of degradation sites occurring in over 70 proteins. An invaluable aid in the rapid identification of potential `hot spots' in proteins, this accessible compilation allows for inspection of the protein's primary structure and preparation of a hydroflex plot.
Poly(Ethylene Glycol) Chemistry
The idea for this book came from discussions among participants in a symposium on biotechnical applications at the "Pacifichem 89" meeting in Honolulu. It was the majority opinion of this group that a volume dedicated to biotechnical and biomedical applications of PEG chemistry would enhance research and development in this area. Though the book was conceived at the Honolulu meeting, it is not a proceedings of this symposium. Several groups who did not participate in this meeting are repre sented in the book, and the book incorporates much work done after the meeting. The book does not include contributions in all related areas to which PEG chemistry has been applied. Several invited researc...
Final Supplemental Environmental Impact Statement
"The Secretaries of Agriculture and the Interior propose limited changes to language about how to implement the Aquatic Conservation Strategy (ACS). The ACS is an integral part of the Northwest Forest Plan. The ACS is intended to maintain and restore the ecological health of watersheds and aquatic ecosystems within the Northwest Forest Plan area"--Summary, p. 1.
