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Preventing Cognitive Decline and Dementia
Societies around the world are concerned about dementia and the other forms of cognitive impairment that affect many older adults. We now know that brain changes typically begin years before people show symptoms, which suggests a window of opportunity to prevent or delay the onset of these conditions. Emerging evidence that the prevalence of dementia is declining in high-income countries offers hope that public health interventions will be effective in preventing or delaying cognitive impairments. Until recently, the research and clinical communities have focused primarily on understanding and treating these conditions after they have developed. Thus, the evidence base on how to prevent or d...
Guía de departamentos universitarios 1989
Guía que se realiza para dar cumplimiento a la Ley 11/83 de Reforma Universitaria y Decretos que la desarrollan.
Autophagy in tumor and tumor microenvironment
This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
Picasso and the War Years, 1937-1945
This absorbing book draws upon new research and works that, in some cases were held out of public view in Picasso's own collection, to explore the critically important--but still under-studied--period of his life from the Spanish Civil War through World War II and the Nazi occupation of France. This span of years is marked by some of the most intensely personal and expressive work of his career. The subjects he painted changed dramatically in direct response first to the horrors of war and then the dangers and privations of life in occupied Paris, where, though branded a degenerate artist by the Nazis, he chose to remain until the Liberation.
Handbook of Research on Tools for Teaching Computational Thinking in P-12 Education
While the growth of computational thinking has brought new awareness to the importance of computing education, it has also created new challenges. Many educational initiatives focus solely on the programming aspects, such as variables, loops, conditionals, parallelism, operators, and data handling, divorcing computing from real-world contexts and applications. This decontextualization threatens to make learners believe that they do not need to learn computing, as they cannot envision a future in which they will need to use it, just as many see math and physics education as unnecessary. The Handbook of Research on Tools for Teaching Computational Thinking in P-12 Education is a cutting-edge r...
In Defense of Israel, Revised
DIVAs Hagee guides readers through the scriptures that explain why Christians need to stand with Israel and the Jews today with as much fervor as God does, they will encounter a man deeply passionate about loving this historic people of God./div
Smart STEM-Driven Computer Science Education
At the centre of the methodology used in this book is STEM learning variability space that includes STEM pedagogical variability, learners’ social variability, technological variability, CS content variability and interaction variability. To design smart components, firstly, the STEM learning variability space is defined for each component separately, and then model-driven approaches are applied. The theoretical basis includes feature-based modelling and model transformations at the top specification level and heterogeneous meta-programming techniques at the implementation level. Practice includes multiple case studies oriented for solving the task prototypes, taken from the real world, by...
Autophagy and Signaling
This book aims to provide an up-to-date overview of the many signaling pathways regulating autophagy in response to different cellular needs. It explores the mechanisms and significance of cross-talk between autophagy and other cellular processes. Lastly, alterations in autophagy observed in aging and age-related pathologies is described.
