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Integrative Multi-Omics for Diagnosis, Treatments, and Drug Discovery of Aging-Related Neuronal Diseases
As the cost of high-throughput sequencing goes down, huge volumes of biological and medical data have been produced from various sequencing platforms at multiple molecular levels including genome, transcriptome, proteome, epigenome, metabolome, and so on. For a long time, data analysis on single molecular levels has paved the way to answer many important research questions. However, many Aging-Related Neuronal Diseases (ARNDs) and Central Nervous System (CNS) aging involve interactions of molecules from multiple molecular levels, in which conclusions based on single molecular levels are usually incomplete and sometimes misleading. In these scenarios, multi-omics data analysis has unprecedent...
Water-Insoluble Drug Formulation
Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-In...
The Involvement of Systemic Homeostasis in Tumour Biology
Systemic homeostatic mechanisms include several aspects, such as metabolic, neuroendocrine, immune, and physiological homeostasis. Irreversible damage or reversible imbalance of such homeostatic processes may initiate cancers by altering the regulation of the molecular machinery. Systemic homeostasis-related genes have been found to be intimately involved in oncological processes and in some instances have shown prognostic value. Thus, future gene targeting approaches for cancer should not only focus on classical cancer drivers but also address systemic homeostasis-related genetic mechanisms. Identification of systemic homeostasis-related genes with diagnostic, prognostic or therapeutic valu...
Empire and Environment in the Making of Manchuria
Since the seventeenth century, Chinese, Japanese, Manchu, Russian, and other imperial forces have defied Manchuria’s unrelenting summers and unforgiving winters to fight for sovereignty over the natural resources of Northeast Asia. Until now, historians have focused on rivalries between the region’s imperial invaders. Empire and Environment in the Making of Manchuria examines the interplay of climate and competing economic and political interests in the region’s vibrant – and violent – cultural narrative. In this unique and compelling analysis of Manchuria’s environmental history, contributors demonstrate how geography shaped the region’s past. Families that settled this borderland reaped its riches while at the mercy of an unforgiving and hotly contested landscape. As China’s strength as a world leader continues to grow, this volume invites exploration of the indelible links between empire and environment – and shows how the geopolitical future of this global economic powerhouse is rooted in its past.
Artificial Intelligence
This three-volume set LNCS 13604-13606 constitutes revised selected papers presented at the Second CAAI International Conference on Artificial Intelligence, held in Beijing, China, in August 2022. CICAI is a summit forum in the field of artificial intelligence and the 2022 forum was hosted by Chinese Association for Artificial Intelligence (CAAI). The 164 papers were thoroughly reviewed and selected from 521 submissions. CICAI aims to establish a global platform for international academic exchange, promote advanced research in AI and its affiliated disciplines such as machine learning, computer vision, natural language, processing, and data mining, amongst others.
The Female Reproductive Tract Microbiome - Gatekeeper for Sexual and Reproductive Health
An optimal female reproductive tract (FRT) microbiome represents a cornerstone for successful reproductive and sexual health. Although understanding the link between the microbiota and our health is the focus of a growing number of research programs and research has advanced in the last decade, the FRT microbiome remains relatively poorly defined. This is despite it being one of the most critical factors impacting fertility and the health of the future generation. Important gaps in our knowledge remain about women-specific microbial niches, such as the lower FRT. The vaginal microbiome of healthy women is almost exclusively dominated by Lactobacillus species, making these species synonymous ...
