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Integrative Multi-Omics for Diagnosis, Treatments, and Drug Discovery of Aging-Related Neuronal Diseases
As the cost of high-throughput sequencing goes down, huge volumes of biological and medical data have been produced from various sequencing platforms at multiple molecular levels including genome, transcriptome, proteome, epigenome, metabolome, and so on. For a long time, data analysis on single molecular levels has paved the way to answer many important research questions. However, many Aging-Related Neuronal Diseases (ARNDs) and Central Nervous System (CNS) aging involve interactions of molecules from multiple molecular levels, in which conclusions based on single molecular levels are usually incomplete and sometimes misleading. In these scenarios, multi-omics data analysis has unprecedent...
Encyclopedia of Curriculum Studies
The Encyclopedia of Curriculum Studies provides a comprehensive introduction to the academic field of curriculum studies for the scholar, student, teacher, and administrator. The study of curriculum, beginning in the early 20th century, served primarily the areas of school administration and teaching and was seen as a method to design and develop programs of study. The field subsequently expanded to draw upon disciplines from the arts, humanities, and social sciences and to examine larger educational forces and their effects upon the individual, society, and conceptions of knowledge. Curriculum studies has now emerged to embrace an expansive and contested conception of academic scholarship w...
Novel Technologies Targeting the Rehabilitation of Neurological Disorders
With the gradual aging of the population, neurological disorders, including stroke, Alzheimer's disease, Parkinson's disease, etc., are causing increasing distress and may even cause the loss of ability to perform activities of daily living. These disorders are generally progressive. Once onset, they may affect the entire life span with subsequent functional impairments such as motor impairment, speech impairment, swallowing impairment, sensory impairment, and cognitive impairment. Rehabilitation therapy is essential for the dysfunction caused by such disorders. Proper rehabilitation programs can improve or compensate for patients' dysfunction, and thus facilitate the restoration of their ability to daily living, help them return to social life, and reduce family and social stress.
A Life of Optimism
This book presents Miriam Ben-Peretz’s world-renowned scholarship as a pioneering female professor, university leader, and founding citizen of Israel. The book features her academic lineage, her signature research, and her collaboration with Israel’s MOFET Institute.
High Performance Computing Systems and Applications
This book constitutes the thoroughly refereed post-conference proceedings of the 23rd International Symposium on High Performance Computing Systems and Applications, HPCS 2009, held in Kingston, Canada, in June 2009. The 29 revised full papers presented - fully revised to incorporate reviewers' comments and discussions at the symposium - were carefully selected for inclusion in the book. The papers are organized in topical sections on turbulence, materials and life sciences, bringing HPC to industry, computing science, mathematics, and statistics, as well as HPC systems and methods.
Potential Biomarkers in Neurovascular Disorders, volume II
Neurovascular disorders are a group of pathological conditions resulting from the neurovascular injury. Neurovascular disorders include cerebral ischemia, intracerebral hemorrhage, subarachnoid hemorrhage, venous sinus thrombosis, glioma, carotid disease, cerebral small vessel disease, and vascular dementia, among others. Although we have accumulated more understanding of both the genetic links and the basic mechanisms behind the pathophysiology of neurovascular diseases over the years, the exact mechanisms are still unclear. Therefore, there is an urgency to identify important therapeutic targets.
