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Pain in Peripheral Nerve Diseases
The book takes a novel approach to the subject of pain in peripheral nerve disease by bringing together basic scientists and clinicians with an expertise in the field of neuropathic pain. For the first time, the description of clinically relevant diseases, an up-to-date review of the pathophysiology of neuropathic pain and a comprehensive review of therapeutic options are combined in one book. Furthermore, the anatomy and pathology of peripheral nerve is outlined in the context of neuropathic pain. Peripheral nerve disorders causing pain, the mononeuropathies and polyneuropathies are described in detail including up-to-date summaries of pathogenesis and treatment. Two chapters elucidate the ...
Peripheral Neurons in Nociception
This book is a review of studies on the physiopharmacology of the peripheral fibres involved in nociception. It examines the substances that are directly or indirectly capable of modifying the activity of these fibres, paying special attention to the part played by physicochemical factors and the sympathetic nervous system. Drawing on the conclusions of eminent pharmacologists, the book not only considers fundamental aspects of the problem but also suggests approaches for research into developing new analgesic molecules. It will be of interest to researchers, pharmacologists, physiologists, physicians and the pharmaceutical industry.
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expectedto provide the basis for entirely new future therapies.
Pharmacology of Pain
Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees
Aspects of Synaptic Transmission
A collection of reviews on selected areas of synaptic transmission from neuroscientists in a number of areas of work in the nervous system and related disciplines. Five areas are covered - long-term potentiation, galanin, autonomic, opioids and 5-hydroxytryptamine.
Galanin
Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and tr...
Neuropeptides in the Spinal Cord
This is the first book devoted exclusively to examining the role of neuropeptides in the spinal cord. Great progress has been made recently in our understanding of the role of neuropeptides in neurotransmission. New tools have been developed to help study the function of endogenous neuropeptides in health and disease. Because the general organization of the spinal cord is well conserved among species and neuropeptides appear to have a major role in spinal neurotransmission, this book is a timely compendium of recent research in this field. The volume will help to stimulate further research in the field of neuropeptides which will lead to better understanding of this role in health and disease.
Cellular Mechanisms of Sensory Processing
The research field of somatosensory processing in mammals has experienced revolutionary changes in recent years. Accumulation of basic and clinical data has greatly accelerated, and new phenomena have emerged. With the aid of new, refined methods, molecular and cellular changes have been described, underlying the signal transduction-transmission between the internal/external environment and the central nervous system have been described. The discovery of the interaction between the nervous and the immune system has, for example changed our view on the development of inflammatory diseases, while the cloning of genes encoding different trophic factors has boosted studies revealing profound cha...
Neuroendocrinology
70 years after the discovery of secretory neurons, internationally leading experts gathered to discuss the latest developments in neuropeptide research and endocrinology, concentrating on the molecular, cellular, supracellular and systemic aspects. A variety of neuropeptidergic systems are considered under comparative and evolutionary aspects.
