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Pharmacokinetics and Metabolism in Drug Design
In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.
The Hemicyoninae
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Molecular Drug Properties
This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and their impact on drug research, screening and combinatorial chemistry libraries, this handbook demonstrates the best and fastest way to estimate those properties most relevant for the efficiency and pharmacokinetic performance of a drug molecule: lipophilicity,solubility, electronic properties and conformation.
Eugène Dubois and the Ape-Man from Java
Although the name Pithecanthropus is now seldom used, there are few who study the origin of our species who will fail to recognise the historical place of the usage and its association with Eugene Dubois. During the last thirty or forty years, Australopithecus and its African context has tended to draw attention from the early work on our origins in Java. It is now increasingly common to hear the term 'pithecanthropine' used only to indicate the Asian or Far Eastern examples of Homo erectus which, although probably derived from African ancestry, have some features that in the opinion of some experts may justify their being considered distinctive. This discussion is not within the pages that follow which deal extensively with the work of Eugene Dubois. He was an extraordinary man who did as much as any person since to put the great antiquity of our ancestors firmly in the public domain. Dubois became involved with the study of human origins from a medical and anatomical background as have many since. The jealousies and professional pressures that we think of as a phenomenon of the post-war years were clearly a major factor in deciding the future of his career.
Drug Bioavailability
The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability. Written by an international team from academia and the pharmaceutical indust...
Naming Our Ancestors
This anthology makes available a set of key documents in the literature of human evolution relevant to the history of hominid taxonomy & the discovery & naming of extinct hominid species.
Preclinical Development Handbook
A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screen...
The First Proofs of the Universal Catalogue of Books on Art
Reprint of the original, first published in 1870.
