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Vaccines against RNA Viruses
  • Language: en
  • Pages: 166

Vaccines against RNA Viruses

  • Type: Book
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  • Published: 2020-12-28
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  • Publisher: MDPI

RNA viruses cause animal, human, and zoonotic diseases that affect millions of individuals, as is being exemplified by the devastating ongoing epidemic of the recently identified SARS-Cov-2. For years vaccines have had an enormous impact on overcoming the global burden of diseases. Nowadays, a vast number of different approaches, from purified inactivated and live attenuated viruses, nucleic acid (DNA or RNA) based candidates, virus-like particles, subunit elements, and recombinant viruses are been employed to combat viruses. However, for many of them efficient vaccines are not yet available. This will probably change dramatically with the current Covid-19 pandemic, as a vast variety of vacc...

Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
  • Language: en
  • Pages: 253

Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?

The considerable number of viral infectious disease threats that have emerged since the beginning of the 21st century have shown the need to dispose global and coordinated responses to fight properly and efficiently against them. Severe acute respiratory syndrome (2003), avian influenza in humans (2005), A(H1N1) pandemic influenza (2009), Middle East respiratory syndrome coronavirus (MERS-CoV) (2012 onward) and Ebola virus disease (2014-2015) are some of the most important examples. The latest emerging and devastating threat was Zika virus, an arbovirus that provoked more than 500,000 suspicious cases in the Americas in 2016 and notable processes of social and medical alarms due to the evide...

Highly Mutable Animal RNA Viruses: Adaptation and Evolution
  • Language: en
  • Pages: 421

Highly Mutable Animal RNA Viruses: Adaptation and Evolution

Viruses are widely present in nature, and numerous viral species with a variety of unique characteristics have been identified so far. Even now, new emerging or re-emerging viruses are being found or re-found as novel viral classes or as quasi-species. Indeed, viruses are everywhere. Of note, viruses are pivotal as targets and tools of basic and applied sciences. On one hand, portions of the viruses are infectious for animals including humans, and cause various diseases in infected hosts by distinct mechanisms and at a different level of severity. While many of viruses are known to co-exist quietly with their hosts, pathogenic viruses certainly affect and threaten our society as well as indi...

Hybrid Artificial Intelligence Systems
  • Language: en
  • Pages: 767

Hybrid Artificial Intelligence Systems

  • Type: Book
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  • Published: 2008-09-30
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  • Publisher: Springer

The Third International Workshop on Hybrid Artificial Intelligence Systems (HAIS 2008) presented the most recent developments in the dynamically expanding realm of symbolic and sub-symbolic techniques aimed at the construction of highly robust and reliable problem-solving techniques. Hybrid intelligent systems have become incre- ingly popular given their capabilities to handle a broad spectrum of real-world c- plex problems which come with inherent imprecision, uncertainty and vagueness, high-dimensionality, and non stationarity. These systems provide us with the oppor- nity to exploit existing domain knowledge as well as raw data to come up with prom- ing solutions in an effective manner. B...

Food-Borne Pathogens
  • Language: en
  • Pages: 265

Food-Borne Pathogens

A collection of readily reproducible classic and emerging molecular methods for the laboratory isolation and identification of the pathogens, viruses, and parasites that cause food-borne disease. Among the pathogens covered are specific bacteria, including Salmonella spp, Campylobacter spp., Listeria spp., and Bacillus spp.; viruses, including noroviruses and enteroviruses; and parasites, including Cryptosporidium and seafood nematode worms. The protocols follow the successful Methods in BiotechnologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

The unfolded protein response in virus infections.
  • Language: en
  • Pages: 130

The unfolded protein response in virus infections.

Unfolded protein response (UPR) is a cellular adaptive response for restoring endoplasmic reticulum (ER) homeostasis in response to ER stress. Perturbation of the UPR and failure to restore ER homeostasis inevitably leads to diseases. It has now become evident that perturbation of the UPR is the cause of many important human diseases such as neurodegenerative diseases, cystic fibrosis, diabetes and cancer. It has recently emerged that virus infections can trigger the UPR but the relationship between virus infections and host UPR is intriguing. On one hand, UPR is harmful to the virus and virus has developed means to subvert the UPR. On the other hand, virus exploits the host UPR to assist in...

New Advances on Zika Virus Research
  • Language: en
  • Pages: 554

New Advances on Zika Virus Research

  • Type: Book
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  • Published: 2019-04-02
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  • Publisher: MDPI

Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

Human Viruses in Water
  • Language: en
  • Pages: 306

Human Viruses in Water

  • Type: Book
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  • Published: 2007-11-07
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  • Publisher: Elsevier

This book provides overviews and updates on basic research, diagnosis, epidemiology, and public health on enteric viruses, as well as on treatment and intervention to prevent their waterborne transmission. Data are presented and interpreted by leading researchers in the field in 13 chapters. An essential resource for virologists, epidemiologists, medical and public health professionals, graduate students and postdoctoral scientists at various levels of their careers. Key Topics Include: * Ecology of enteric viruses * Intervention measures from risk assessment to virus disinfection practices * Cutting edge technology on procedures for virus detection and monitoring in water and the water environment * Quality assurance and quality control measures in water virology * Legal regulations regarding viruses in the environment

Antivirals for Emerging Viruses: Vaccines and Therapeutics
  • Language: en
  • Pages: 373

Antivirals for Emerging Viruses: Vaccines and Therapeutics

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Viral Infections and Global Change
  • Language: en
  • Pages: 655

Viral Infections and Global Change

A timely exploration of the impact of global change on the emergence, reemergence, and control of vector-borne and zoonotic viral infections From massively destructive "superstorms" to rapidly rising sea levels, the world media is abuzz with talk of the threats to civilization posed by global warming. But one hazard that is rarely discussed is the dramatic rise in the number and magnitude of tropical virus outbreaks among human populations. One need only consider recent developments, such as the spread of chikungunya across southern Europe and dengue in Singapore, Brazil, and the southern United States, to appreciate the seriousness of that threat. Representing a major addition to the world ...