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This book surveys the current knowledge concerning the expression and function of stress proteins in different organisms, ranging from prokaryotes to humans. It provides an overview of the diversity and complex evolutionary history of cell stress proteins and describes their function and expression in different eukaryote models. The book will appeal to researchers and scientists in biochemistry, cell biology, microbiology, immunology, and genetics.
The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses. Since the promulgation of the ‘molecular chaperone’ concept as a general cellular function to control the process of correct protein folding, a large number of molecular chaperones and protein folding catalysts have been identified, and it has been recognized tha...
Martin Bowmanâs considerable experience as a military historian has spanned over forty years, during which time he has spent hundreds of hours interviewing and corresponding with numerous men and women and their relatives, in Britain, America and beyond, resulting in a wealth of material on the war at sea from World War One to the Falklands and the wars on terror. All these narratives have been woven into a highly readable and emotional outpouring of life and death in action in all his titles, as here, in World War Two, where the men of the Fleet Air Arm and the US Navy fighter (operating bomber and torpedo carrying aircraft) describe the compelling, gripping and thought-provoking narrative of the air war in the freezing Atlantic wastes to the waters of the mighty Pacific.
This book provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulate the hosts’ immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step-wise fashion take the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provide answers as to its biological significance to the host.
With vivid firsthand accounts, this WWII history examines the RAF Coastal Command’s operations at sea against U-boats and the German Navy. In Deep Sea Hunters, historian Martin Bowman delves into the Royal Air Force Coastal Command’s dynamic role in countering German naval power during the Second World War. Beginning with the disastrous Norwegian Campaign, he covers the numerous attacks on the bustling German submarine base at Lorient, the attack on Brest, as well as many other pivotal and dramatic events of the conflict at sea. The hunt or U-boats is relayed in full and gripping detail, with first-hand accounts from U-boat attackers—as well as German submariners—punctuating Bowman’s dramatic prose. This two-sided history is sure to appeal to all enthusiasts interested in gaining a balanced insight into Second World War naval history.
Heat shock proteins are a distinctive class of proteins that have evolved to cope with stress and to provide cellular defense against a wide range of cell injuries. Cellular stress responses include a transient rearrangement of functional activities in order to protect and maintain essential cellular functions. The science of stress responses in various renal diseases is a new and still evolving medical discipline which offers the prospect of new alternate therapeutic options. This publication provides basic information about the important role of stress proteins in several renal diseases, ranging from hypoxic injuries to fibrotic renal disorders and tumors. Each chapter is written in a clea...
An illustrated examination of the role played by the Sunderland as an antisubmarine aircraft during the Battle of the Atlantic, focusing on the key battles of the Biscay campaign in 1943–44. The Sunderland is an iconic British aircraft of World War II, and the only RAF Coastal Command type to perform frontline service throughout the conflict. Its prime target – the German U-boat – was a deadly adversary to Allied warships and other oceangoing vessels, but proved vulnerable to detection and air attacks from the radar-equipped Sunderland. This book examines the respective advantages and drawbacks of these two maritime predators by providing a vivid analysis of their historic engagement during the Biscay campaign in 1943–44. Drawing upon first-hand accounts of this famous duel, Mark Lardas tells the story of how highly skilled Sunderland crews took the fight to an often elusive enemy and helped RAF Coastal Command defeat the U-boat threat. Maps, tactical diagrams, photographs and specially commissioned artwork bring the action to life as the Sunderland's losses – and eventual victory – in the Bay of Biscay play out in fascinating, insightful detail.
At the outbreak of World War II, somewhat by accident — and just as the first shots of the war were fired — young Australian airmen from the Royal Australian Air Force were engaged in operations that would become known collectively as the Battle of the Atlantic. Arguably lesser-known than air campaigns in other theatres, large numbers of Australians who volunteered for service with Royal Australian Air Force, found themselves fighting in this battle. Australians were there at the outbreak and many would go on to fly some of the final missions of the war in Europe. This book captures some of the experiences of the Royal Australian Air Force members who served with Coastal Command and, thr...
It has been known for over 150 years that hallmarks of inflammation can be observed in the wall of atherosclerotic vessels. It was, however, not clear if this inflammation is the cause or the consequence of atherogenesis. More recently, it has become evident that inflammation mediated both by innate and adaptive immunity is instrumental even in the earliest stages of the development of atherosclerotic lesions, i.e., that it plays an important pathogenetic role. In this volume, international experts in the field discuss the pathogenetic, diagnostic, preventive and possible therapeutic relevance of inflammation in atherogenesis. This book is intended for researchers and physicians in the fields of vascular biology, immunology and atherosclerosis.
There have been several books published about the wartime experiences of individual air gunners but there is no general history of Air Gunners, their equipment, training or service in the various RAF Commands in which they served. This book explains in great detail how and why the trade of air gunner was developed at the outset of World War II. Chapters include the history of the guns and turrets, the famous gunners, outstanding bravery during major raids, flying with Coastal Command, Bomber Command and overseas operations. It also includes the history of Air Gunners who became prisoners of war, outstanding bravery awards and American air gunners such as Clark Gable, John Huston and Charlton Heston. It includes many first-hand accounts of wartime combat as seen from the gun turret in the heat of battle. Air Gunners, tail-end Charleys in particular, have always been popular wartime heroes as they flew in their isolated positions protecting their aircraft from enemy fighter attack in the skies over war torn Europe.