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The Pharmacology of Pain
  • Language: en
  • Pages: 494

The Pharmacology of Pain

Pain is a symptom of many clinical disorders, afflicts a large proportion of the population and is largely treated by pharmacological means. However, the two main classes of drugs used are the opioids and the non-steroidal anti inflammatory drugs, drugs that have a long history. The last decade has seen remarkable advances in our understanding of some of the pharmacological bases of pain and analgesia and this book aims to reflect these rapid changes in our understanding of pain mechanisms. One impetus to these scientific advances has been dialogue and interactions between scientists and clinicians; as a result we now has a number of animal models of clinical pain states, to mimic certain as...

Galanin
  • Language: en
  • Pages: 285

Galanin

Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and tr...

Cold Chemistry
  • Language: en
  • Pages: 692

Cold Chemistry

Explores the theoretical and experimental aspects of cold and ultracold molecular collisions, for students and researchers in theoretical chemistry and chemical reaction/molecular dynamics.

Functional Neuroanatomy of Pain
  • Language: en
  • Pages: 126

Functional Neuroanatomy of Pain

Pain is an unpleasant but very important biological signal for danger. Nociception is necessary for survival and maintaining the integrity of the organism in a potentially hostile environment. Pain is both a sensory experience and a perceptual metaphor for damage and it is activated by noxious stimuli that act on a complex pain sensory apparatus. However, chronic pain having no more a protective role can become a ruining disease itself, termed "neuropathic pain".

Peripheral Neurons in Nociception
  • Language: en
  • Pages: 292

Peripheral Neurons in Nociception

This book is a review of studies on the physiopharmacology of the peripheral fibres involved in nociception. It examines the substances that are directly or indirectly capable of modifying the activity of these fibres, paying special attention to the part played by physicochemical factors and the sympathetic nervous system. Drawing on the conclusions of eminent pharmacologists, the book not only considers fundamental aspects of the problem but also suggests approaches for research into developing new analgesic molecules. It will be of interest to researchers, pharmacologists, physiologists, physicians and the pharmaceutical industry.

Mechanisms and Mediators of Neuropathic Pain
  • Language: en
  • Pages: 278

Mechanisms and Mediators of Neuropathic Pain

  • Type: Book
  • -
  • Published: 2012-12-06
  • -
  • Publisher: Springer

Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury initiates a cascade of events resulting in altered neurochemistry and molecular biology of the peripheral neurons, the dorsal root ganglion cell, and changes in neurotransmitter and receptor expression in the dorsal horn of the spinal cord. Moreover, nerve injury produces anatomical changes with functional consequences. This volume summarises the current understanding of the pathophysiological processes in the peripheral and central nervous system that contribute to the neuropathic pain. It provides a timely review of neuropathic pain mechanisms, written by experts in the field.

Cumulated Index Medicus
  • Language: en
  • Pages: 1328

Cumulated Index Medicus

  • Type: Book
  • -
  • Published: 1996
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  • Publisher: Unknown

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Sensory Mechanisms of the Spinal Cord
  • Language: en
  • Pages: 604

Sensory Mechanisms of the Spinal Cord

The third edition of this monograph continues to have the goal of providing an overview of current thought about the spinal cord mechanisms that are responsible for sensory processing. We hope that the book is of value to both basic and clinical neuroscientists. Several changes have been made in the presentation, as well as additions because of the research advances that have been made during the past decade. Chapters 3 and 4 in the previous edition have been subdivided, and now the morphology of primary afferent neu rons of the dorsal root ganglia is described in Chapter 3 and the chemical neuroanatomy 4. The description of the dorsal hom in the previous Chapter 4 of these neurons in Chapte...

Semiconductors and Semimetals
  • Language: en
  • Pages: 405

Semiconductors and Semimetals

Semiconductors and Semimetals

Neuroendocrinology
  • Language: en
  • Pages: 416

Neuroendocrinology

There has been an explosion of interest in the field of neuroendocrinology over the last twenty years with the discovery of neurohormones regulating virtually everything from growth and development to sexual and aggressive behavior. This book provides a much-needed introduction to neuroendocrinology from a zoological and evolutionary perspective. It covers the evolution, development and description of the neuroendocrine system throughout the animal kingdom. Specific topics covered include: The Evolution of early neuroendocrine systems in primitive animals Structural characterisation, molecular biology and biochemistry of neuroendocrine agents A profiles section on unusual aspects of neuroendocrine physiology written by leaders in the field A unique section on the actions of environmental chemicals effect neuroendocrine systems in various species