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Aditya
After finally completing a long and protracted case, Aditya, an investigative journalist, recalls about his girlfriend, Anamika, whom he had been too preoccupied to speak with. He calls her, intrigued by her mention of a remote area and her request for him to unravel the mysteries of a perplexing case—an unheard-of place to anyone else. When he arrives, all he finds is calm and serenity, a stark contrast to Anamika's description. However, his quest takes a monumental turn when he becomes ensnared in an inferno-like situation. Flames rage around him, threatening to consume everything in their path. Aditya must emerge unscathed from this fiery ordeal, or else succumb to the relentless heat.
Differential Trafficking of Ligands Trogocytosed Via CD28 Versus CTLA4 Promotes Collective Cellular Control of Co-stimulation
Abstract: Intercellular communication is crucial for collective regulation of cellular behaviors. While clustering T cells have been shown to mutually control the production of key communication signals, it is unclear whether they also jointly regulate their availability and degradation. Here we use newly developed reporter systems, bioinformatic analyses, protein structure modeling and genetic perturbations to assess this. We find that T cells utilize trogocytosis by competing antagonistic receptors to differentially control the abundance of immunoregulatory ligands. Specifically, ligands trogocytosed via CD28 are shuttled to the T cell surface, enabling them to co-stimulate neighboring T cells. In contrast, CTLA4-mediated trogocytosis targets ligands for degradation. Mechanistically, this fate separation is controlled by different acid-sensitivities of receptor-ligand interactions and by the receptor intracellular domains. The ability of CD28 and CTLA4 to confer different fates to trogocytosed ligands reveals an additional layer of collective regulation of cellular behaviors and promotes the robustness of population dynamics
Miles Away From Home
In a world post ‘The Great War’ fought against aliens around 100 years from now, Captain Miles was happy and content with his drone command unit at the Amerope Police Department headquarters. A job he loved and made himself available on a call’s notice for the department. He was content with his life—with his team, with Angela, the love of his life, and his cute little son’s smile by his side—not knowing he would be sent on a secret mission full of betrayals and tribulations. He was left alone to trust his conscience with a pledge to continue serving his country, not knowing whom to trust anymore. He must unearth a conspiracy threatening the existence of this world and, most notably, the safety of his own family. The story of Captain Miles is a teenage sci-fi thriller filled with action, love, emotions, family values, conflicts, inventions, and so much more to take you to a world so different yet so similar to today’s world.
Self Disguised Order : We Call it Development
The climate movement has now been receiving a significant acknowledgment, especially among the younger lot, which is a sign imbued with hope. The issue of water scarcity is not much adequate to be described within its social aspects, the worst result being chaos and violence over the issue of possession of water resources. Air pollution is one of the natural-cum-anthropogenic factors which affects us directly and has the widest possible area for its effects since air is an all-pervasive element. The taking up of these three issues for elaboration in this book is characterized by the purpose of exhibiting the above-mentioned results of the activities performed by our species. This book also i...
Be Successful
Be Successful - Thrive Exponentially Beyond Excellence is Aditya Bhavsar's best-selling self-help book that will surely help its reader to fill the gap between their current situation and dreams.
Desk29
Jericha is also with Lapras. Both are on a adventure that they both will regret. They went to place where they could die but a new character came outta nowhere and helped them. Now it's time for Lapras to complete what he has started.
Gaming Culture(s) in India
This volume critically analyzes the multiple lives of the "gamer" in India. It explores the "everyday" of the gaming life from the player’s perspective, not just to understand how the games are consumed but also to analyze how the gamer influences the products’ many (virtual) lives. Using an intensive ethnographic approach and in-depth interviews, this volume situates the practice of gaming under a broader umbrella of digital leisure activities and foregrounds the proliferation of gaming as a new media form and cultural artifact; critically questions the term gamer and the many debates surrounding the gamer tag to expand on how the gaming identity is constructed and expressed; details pa...
Pro HTML5 Games
Build your next game on a bigger scale with Pro HTML5 Games. This book teaches you the essentials of advanced game programming in HTML5. You’ll learn techniques that you can transfer to any area of HTML5 game development to make your own professional HTML5 games! Led by an expert game programmer, you’ll build two complete games in HTML5: a strategy puzzle game based on the Box2d physics engine and in the style of Angry Birds and a real-time strategy (RTS) game complete with units, buildings, path-finding, artificial intelligence, and multiplayer support. In the process, you’ll learn how to do the following: Create realistic physics in your game by incorporating the Box2d physics engine...
