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Molecular Targets in Oncological and Hematological Disease Management: Innovations in Precision Medicine
Targeted therapies use specific therapeutic agents that specifically target a molecule that is involved in disease progression. By targeting these specific molecules, the molecular pathway of the disease development could be modulated thus inhibiting the disease progression. By specifically targeting a molecule involved in disease development, we can overcome potential side effects, increasing the precision of the treatment. Precision medicine approaches have been particularly successful in the field of oncology, where targeted therapies have been tested and developed for specific mutations or molecules that promote tumor growth. This Research Topic is centered around the use of therapeutic ...
Economic Recovery After COVID-19
These proceedings constitute a selection of best papers from the 3rd International Conference on Economics and Social Sciences, Innovative Models to Revive the Global Economy, ICESS 2020, held in Bucharest, Romania, in October 2020. This book is a collection of research findings and perspectives related to recent economic challenges determined by the global crisis due to COVID 19, led by the set of improvements and changes in the economic, societal, and technological structures and processes towards the effort of reaching the sustainability goals. During a crisis, countries, and businesses must respond promptly to ensure survival. They need to rethink social contracts, redefine work and consumption, mobilize resources at speed and scale, and at the same time rethink patterns from global to local. The innovative models presented in this book aim to ensure simultaneous economic development, social development, and environmental protection, to achieve a higher quality of life for all people, and protect all living beings and the planet.
Immune Homeostasis
Many questions remain unresolved as researchers continue to characterize and define the nature of normal immune homeostasis and determine how these processes are dysregulated in immunodeficiency, as well as in autoimmune and lymphoproliferative disorders. Immune Homeostasis: Methods and Protocols focuses on experimental techniques for measuring and analyzing immune cell dynamics, with a particular emphasis on examining lymphocyte programmed cell death in different contexts. With contributions by leading experts in the field, the collection examines detailed protocols for studying various pathways of apoptosis and necrosis in different types of hematopoietic cells, both in vitro and in vivo, ...
Limba română
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The Tumour Microenvironment
Several fundamentally important questions form the basis for this book. What are the relationships between tumour formation and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH? It is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy. Better understanding of the influence of pH on tumour growth, coupled with manipulation of the pH of the tumour microenvironment, may lead to the development of more effective therapies.
Design and Manufacturing
In product development, decisions taken in design and manufacturing are considered the most influential factors for succeeding commercialisation. Product development is a complex integrated process of several steps starting from design where the market needs are identified and turned into competitive product specifications and different design concepts. In other words, design is about identifying a problem, developing solution proposals, and validating the most feasible solution with real users. Manufacturing technologies, on the other hand, help designers to make those virtual models into physical parts by transforming different types of raw materials. This book on design and manufacturing, written by a number of experts from all over the world, presents a design perspective and different manufacturing applications from various industrial sectors.
Practical Clinical Oncology
A complete guide to clinical oncology, covering the main treatment modalities and diagnosis and treatment strategies for specific tumour types.
Heritage, Memory and the Politics of Identity
The study of the cultural landscape has gained momentum in recent years, revealing new insights to geographers, archaeologists, sociologists and architects. The cultural landscape is often viewed as an emblematic site and thus a key player in the heritage process. This book explores the overlapping and often complex relationships between identity, memory, heritage and the cultural landscape. It provides an overview of new approaches in the study of these relationships, combined with evidence from Ireland, England, Scotland and the United States. These case studies demonstrate the significance of the past in the contemporary construction of identity narratives and draw attention to the powerful role of monuments and parades as sites of cultural heritage. The focus then shifts to the way in which heritage has become politicized for various ends, demonstrating the changing perception of particular heritage sites and buildings, and the role that this has played in constructing and reconstructing particular identities.
