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ImmunoPharmaceuticals
Written by a leading researcher in immunology, ImmunoPharmaceuticals specifically focuses on immunologically active drugs recently tested for clinical activity or recently approved for medical use. Each chapter focuses on a single drug or class of drugs and discusses data from basic and preclinical research concerning mechanisms of action. Preclinical models are compared with clinical findings to allow the reader to evaluate the predictive value of those models. Featured drugs are being studied for therapy of cancer, arthritic disease, autoimmune disease, immunodeficiency disease, transplantation, and determination of sepsis. Overviews of the retinoids in cancer therapy and preclinical studies on flavonoids are featured.
Annual Report of the National Advisory Committee for Aeronautics
Includes the Committee's Reports no. 1-1058, reprinted in v. 1-37.
Handbook of Targeted Delivery of Imaging Agents
This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chap...
Adaptive Optics Engineering Handbook
This handbook supplies analytical tools for the design and development of adaptive optics systems to enhance their ability to adjust for atmospheric turbulence, optical fabrication errors, thermally induced distortions, and laser device aberrations. It provides recommendations for selecting, testing and installing a wavefront compensation system.
The Architecture of Downtown Troy
Winner of the 2021 Antoinette Forrester Downing Book Award presented by the Society of Architectural Historians Winner of the 2020 Excellence in Historic Preservation Award presented by the Preservation League of New York State Located about 150 miles north of Manhattan, on the east bank of the Hudson River, the city of Troy, New York, was once an industrial giant. It led the nation in iron production throughout much of the nineteenth century, and its factories turned out bells and cast-iron stoves that were sold the world over. Its population was both enterprising and civic-minded. Along with Troy's economic success came the public, commercial, educational, residential, and religious buildi...
Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m)
Many therapeutic interventions for autism spectrum disorder fail when they are examined in a clinical trial. Frequently, there is a subset of patients that responds very well to the intervention, while others do not, and the overall result does not yield a positive result. As autism spectrum disorder is highly heterogeneous in its underlying genetics and other etiological risk factors, as well as its heterogeneous phenotypic manifestation, this variability in response to any specific treatment is not entirely surprising. However, it remains a challenge to meaningfully subtype this heterogeneity for targeted treatment. The purpose of this research topic is to solicit articles that address the...
