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The Middle Ages were a time of great innovation in shipbuilding, yet medieval maritime technology is often overlooked. This book traces the developments in rigging and shipbuilding in northern Europe over the medieval period, such as the adoption of the lateen rig with two or more masts.
The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.
This book covers the period from about 1000 A.D. to 1500 A.D., and shows how the peoples of north-west Europe and the Mediterranean came to terms with the sea, what kind of boats were used and how they were built. It also answers questions such as how easy was it to navigate on short or long passages; whether trade by sea was crucial to the economy of this area; how the sea was represented in poems and other writings; and what life was like for those who went to sea or who lived by its shores." "Susan Rose shows how European maritime adventurers and merchants acquired the tools and the confidence to extend their influence to the oceans of the world, opening the way to the modern era. The Medieval Sea is the first book to treat this subject in an inclusive and accessible way.
This annual publication is a record of the IMF's Annual Meeting and contains the opening and closing addresses of the Chairman of the Board of Governors, presentation of the Annual Report by the Managing Director, statements of Governors, committee reports, resolutions, and a list of delegates. Usually published in March.
This is a basic introduction to evidence-based medicine describing the need for EMB and the tools used. The book guides the reader towards finding the right evidence and how to assess its value and quality, including a section on the Internet and how to make best use of it.
The combined challenges of health, comfort, climate change and energy security cross the boundaries of traditional building disciplines. This authoritative collection, focusing mostly on energy and ventilation, provides the current and next generation of building engineering professionals with what they need to work closely with many disciplines to meet these challenges. A Handbook of Sustainable Building Engineering covers: how to design, engineer and monitor a building in a manner that minimises the emissions of greenhouse gases; how to adapt the environment, fabric and services of existing and new buildings to climate change; how to improve the environment in and around buildings to provide better health, comfort, security and productivity; and provides crucial expertise on monitoring the performance of buildings once they are occupied. The authors explain the principles behind built environment engineering, and offer practical guidance through international case studies.
A reprint of Wagner's classic study of the 30 Year's War period The Thirty Years’ War, which encompassed the entire European continent, was one of the great watersheds of European history. It was a war which involved religious, political and economic contentions. And it was one which changed the face of Europe irreversibly. European Weapons and Warfare 1618-1648 is a minutely-detailed survey of the armies of this extraordinary period. It discusses the developments in strategy and organization and demonstrates these with full diagrams. The techniques of hand-to-hand combat, together with edged weapons, hand guns, artillery and fortifications, are clearly illustrated with drawings taken from...
Grapevine is one of the most widely cultivated plant species worldwide. With the publication of the grapevine genome sequence in 2007, a new horizon in grapevine research has unfolded. Thus, we felt that a new edition of ‘Molecular Biology & Biotechnology of the Grapevine’ could expand on all the latest scientific developments. In this edition and with the aid of 73 scientists from 15 countries, ten chapters describe new aspects of Grapevine Molecular Physiology and Biotechnology and eleven chapters have been revised and updated. This book is intended to be a reference book for researchers, scientists and biotechnological companies, who want to be updated in viticultural research, but also it can be used as a textbook for graduate and undergraduate students, who are interested in the Molecular Biology and Biotechnology of Plants with an emphasis on the Grapevine.