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Current Advances in Amyotrophic Lateral Sclerosis
Our understanding of the pathology of amyotrophic lateral sclerosis is a continuously changing field. New hypotheses are generated with each new discovery; they are abandoned to be reanalyzed after some time under the light of new observations. This book present a series of reviews from experts in different aspects of the disease focus on these hypotheses. There are also a few review chapters providing clear examples of these new observations that make the field to reanalyze previous conclusions.
Redox-Active Therapeutics
This essential volume comprehensively discusses redox-active therapeutics, focusing particularly on their molecular design, mechanistic, pharmacological and medicinal aspects. The first section of the book describes the basic aspects of the chemistry and biology of redox-active drugs and includes a brief overview of the redox-based pathways involved in cancer and the medical aspects of redox-active drugs, assuming little in the way of prior knowledge. Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerative diseases, pain, radiation injury and radioprotection (such as of brain, lungs, head and neck and erectile function) and neg...
Before Middle Passage: Translated Portuguese Manuscripts of Atlantic Slave Trading from West Africa to Iberian Territories, 1513-26
On the 20th of January 1526, the Santiago left Lisbon bound for Africa with a cargo of brass and tin bracelets, round bells, barber basins and cloth; by early October the ship was back in Portugal with a very different cargo, 108 enslaved Africans. With chilling detachment the ship’s trading log records the commodification of human beings, the prices paid for them, the sums received for their sale and the number who did not survive the crossing. Whilst this log may be extremely rare, it is clear from another surviving document, the receipt book of the customs office of the Portuguese Cape Verde Islands, that such voyages were commonplace in the early years of the sixteenth century. The bul...
Cerebrovascular Disease
Prevention, diagnosis and treatment are the watchwords in stroke research, for basic neuroscientists and clinicians alike. This 2002 book, from the 22nd Princeton Conference on Cerebrovascular Disease, contains contributions from outstanding investigators on numerous topics in stroke research. The contents cover the status and future directions of stroke pathophysiology, diagnosis and treatment, with special emphasis on the molecular and cellular mechanisms of ischaemic cell death and repair, and clinical issues including imaging, risk factors and therapeutic strategies in stroke. Available in both print and online formats, this survey of the basic and clinical science of stroke is an essential resource for all involved in advancing knowledge of cerebrovascular disease.
Amyotrophic Lateral Sclerosis
Though considerable amount of research, both pre-clinical and clinical, has been conducted during recent years, Amyotrophic Lateral Sclerosis (ALS) remains one of the mysterious diseases of the 21st century. Great efforts have been made to develop pathophysiological models and to clarify the underlying pathology, and with novel instruments in genetics and transgenic techniques, the aim for finding a durable cure comes into scope. On the other hand, most pharmacological trials failed to show a benefit for ALS patients. In this book, the reader will find a compilation of state-of-the-art reviews about the etiology, epidemiology, and pathophysiology of ALS, the molecular basis of disease progression and clinical manifestations, the genetics familial ALS, as well as novel diagnostic criteria in the field of electrophysiology. An overview over all relevant pharmacological trials in ALS patients is also included, while the book concludes with a discussion on current advances and future trends in ALS research.
Nitric Oxide
This volume explores the biological activity and potential clinical causes of nitric oxide (NO), a gas that plays important roles in the regulation of blood pressure, the immune system, and brain function. It reviews the potential beneficial effects of nitric oxide, cGMP and phosphodiesterases, in addition to their role as endothelial dependent relaxing factor (EDRF, 1998 Nobel Prize). Novel actions of NO and cGMP discussed in this work include anti-apoptosis, the preconditioning adaptation mechanism, cardio- and neuro-protective effects, anti-viral or anti-protease effects, and a possible role of cGMP in gene expression or induction. The known detrimental actions of iNOS (NOS2), peroxynitrite and reactive nitrogen species are discussed. The results of safety and clinical trials of several newly-designed nitric oxide compounds with potential anti-inflammatory activity are disclosed.
Frontiers in Cardiovascular Medicine: Rising Stars 2023
We are delighted to present the 2023 Frontiers in Cardiovascular Medicine “Rising Stars” article collection. This collection showcases the high-quality work of internationally recognized researchers in the early stages of their independent careers. All Rising Star researchers were individually nominated by the Chief Editors of the Journal in recognition of their potential to influence the future directions in their respective fields. The work presented here highlights the diversity of research performed across the entire breadth of cardiovascular medicine, including the elucidation of fundamental biology, the development of novel diagnostics or therapeutics, computational modelling approaches, and bioengineering strategies for regeneration.
Esmeraldo de situ orbis, by Duarte Pacheco Pereira
The translation and edition of a Portuguese account of the coasts of Africa and their discovery, written c.1505-1508. This is a new print-on-demand hardback edition of the volume first published in 1937.
