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This 1996 book, based upon a vast range of documentary and secondary sources, shatters the disproven but persistent myth of the closed immobile village in the early modern period. It demonstrates that even in traditionalist Castile, pre-industrial village society was highly dynamic, with continuous inter-village, inter-regional, and rural-urban migration. The book is rich in human detail, with many vignettes of everyday life. Professor Vassberg examines such topics as fairs and markets, the transportation infrastructure, rural artisans and craftsmen, relations with the state, and life-cycle service. The approach is interdisciplinary, and pays special attention to how rural families dealt with economic and social problems. The rural Castile that emerges is a complex society that defies easy generalizations, but one which is unquestionably part of the general European reality.
The fungal genus Botrytis is the focus of intensive scientific research worldwide. The complex interactions between this pathogen and the plants it infects and the economic importance of the diseases caused by Botrytis (principally grey mould) on more than 1400 species of cultivated plants pre- and post-harvest, render this pathogen of particular interest to farmers, advisers, students and researchers in many fields worldwide. This 20-chapter book is a comprehensive treatise covering the rapidly developing science of Botrytis and reflecting the major developments in studies of this fungus. It will serve as a source of general information for specialists in agriculture and horticulture, and also for students and scientists interested in the biology of this fascinating, multifaceted phytopathogenic fungal species.
Intraocular Pressure is the subject for the fourth Consensus report published under the auspices of the AIGS, now renamed as the World Glaucoma Association (WGA). The active participation in our Project Forum e-Room started in January, 2007, by expert members of the various consensus committees. As done with prior reports, the preliminary document was circulated to each of the member societies of the WGA, and additional comments were solicited for the document. Each member Society also was invited to send a representative to attend the consensus meeting that was held in Fort Lauderdale, Florida on May 5, 2007. The report then was discussed extensively during the Consensus Meeting and Consens...
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The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T-cell engager (BITES), Dual Variable Domain (DVD) antibodies, and fusion proteins that are currently being used as therapeutic agents for immunology, oncology and other disease conditions. Regulatory agencies have raised the bar for the development and manufacture of antibody-based products, expecting to see the use of Quality by Design (QbD) elements demonstrating an in-depth understanding of product and process based on sound science. Drug delivery systems have become an increasingly important part of the therapy and most...