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Methods in Endothelial Cell Biology
Endothelial cell biology has developed into a vibrant discipline and has become a critical instrument to study several disease processes on the cellular and molecular level. It is now widely recognized that dysfunctions of normal endothelial cell homeostasis are involved in some of the most important human diseases, including ischemic heart diseases, hypertension, atherosclerosis, tumors, diabetes, arthritis, and inflammation. Further, the increasing importance and recognition of the field of vascular biology in general requires in vitro and in vivo techniques in order to address the complex questions. Methods in Endothelial Cell Biology is a comprehensive practical "how-to"-guide summarizing the most relevant established techniques as well as a number of new emerging techniques. Easy-to-follow reliable protocols provide a useful lab bench resource for the experienced researcher and newcomer to the field.
The G3BP1-UPF1-associated Long Non-coding RNA CALA Regulates RNA Turnover in the Cytoplasm
Besides transcription, RNA decay accounts for a large proportion of regulated gene expression and is paramount for cellular functions. Classical RNA surveillance pathways, like nonsense-mediated decay (NMD), are also implicated in the turnover of non-mutant transcripts. Whereas numerous protein factors have been assigned to distinct RNA decay pathways, the contribution of long non-coding RNAs (lncRNAs) to RNA turnover remains unknown. Here we identify the lncRNA CALA as a potent regulator of RNA turnover in endothelial cells. We demonstrate that CALA forms cytoplasmic ribonucleoprotein complexes with G3BP1 and regulates endothelial cell functions. A detailed characterization of these G3BP1-positive complexes by mass spectrometry identifies UPF1 and numerous other NMD factors having cytoplasmic G3BP1-association that is CALA-dependent. Importantly, CALA silencing impairs degradation of NMD target transcripts, establishing CALA as a non-coding regulator of RNA steady-state levels in the endothelium.
AHA Scientific Sessions 2016: Program Information
The American Heart Association’s Scientific Sessions 2016 is bringing big science, big technology, and big networking opportunities to New Orleans, Louisiana this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
Andrea Buttner Hidden Marriageshb
"This artists's book was conceived by Andrea Büttner as part of her research into the collections of Amgueddfa Cymru - National Museum Wales."--Colophon.
German Immigrants
The second volume of German Immigrants provides information on about 35,000 German immigrants from Bremen who arrived in New York from 1855 to 1862. The names are arranged alphabetically, and family members are grouped together, usually under the head of the household. In addition, data on age, place of origin, date of arrival, and the name of the ship are supplied, plus citations to the original source material.
Resilience and the Virtue of Fortitude
The book offers a renewed, classic vision of the human person and the ordering of the sciences as read through the complementary and, at one level, corrective insights of empirical psychosocial studies on resilience.
Borders and Freedom of Movement in the Holy Roman Empire
Borders and Freedom of Movement in the Holy Roman Empire tells the history of free movement in the Holy Roman Empire of the German Nation, one of the most fractured landscapes in human history. The boundaries that divided its hundreds of territories make the Old Reich a uniquely valuable sitefor studying the ordering of movement. The focus is on safe-conduct, an institution that was common throughout the early modern world but became a key framework for negotiating free movement and its restriction in the Old Reich. The study shows that attempts to escort travellers, issue letters ofpassage, or to criminalize the use of "forbidden" roads served to transform rights of passage into excludable ...
