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Malignancies are frequent complications in organ transplantation, mainly as the result of infection with certain viruses and of long-term immunosuppression. The epidemiology confirms that the increased incidence concerns certain cancers, especially HIV-related skin cancers and EBV-related lymphoproliferative malignancies. This book covers all currently available information on this important topic of the relationships between transplantation and malignancies: preexisting cancers, posttransplant cancers, their etiology and pathophysiology, their prevention and treatment. A significant part of the volume is devoted to prophylaxis, early detection and modern forms of therapy in posttransplant lymphomas. As a conclusion of all these new data, the theory of immunosurveillance deserves to be significantly modified.
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Germany and Britain are two major European economies that have been trying to confront the challenges of globalisation in very different ways. Britain has favoured market liberal strategies; Germany has endeavoured to retain its tradition of consensualism and the strong welfare state. Focusing on the period since 1997/8, this book explores the controversies and struggles surrounding the agendas of social, economic, and political modernisation in the two countries. The New Labour governments in Britain and the Social Democratic coalition governments in Germany have been introducing a range of reform policies designed to reform the welfare state and increase the respective country's competitiv...
80 years ago the greatest mass murder of human beings of all time occurred in Nazi occupied Europe. This began with the mass extermination of patients with neurological and psychiatric disorders. This book is the only comprehensive and scholarly published work regarding the ethical and professional abuses of neuroscientists during the Nazi era.
"This book examines the experiences of ethnic Germans fleeing the Russian advance into Eastern Europe, German civilians seeking refuge from bombed-out urban areas, non-Germans liberated from concentration camps or compulsory labor facilities, refugee bureaucrats from both Germany and the United Nations, American soldiers and erstwhile occupiers, and the community of Wildflecken itself"--Jacket.
The book contains a series of up-to-date review articles on the physiology and pathophysiology of the control of the production of red cells by the hormone erythropoietin. In addition, the results are reported of initial clinical trials using recombinant human erythropoietin (rhuEpo) in the treatment of the anemia of renal failure. The introductory chapter briefly recalls the history of erythropoietin research. The following section on the chemistry and physiology covers details of the structure of the hormone, assay methods, the identification of renal and extrarenal sites of the production of erythropoietin by in situ hybridization and the hypoxic stimulation of its production. A special c...