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Fibrous Proteins: Amyloids, Prions and Beta Proteins
Amyloids, Prions and Beta Proteins is the last volume of the three-part thematic series on Fibrous Proteins in the Advances in Protein Chemistry serial. Fibrous proteins act as molecular scaffolds in cells providing the supporting structures of our skeletons, bones, tendons, cartilage, and skin. They define the mechanical properties of our internal hollow organs such as the intestines, heart, and blood vessels. This volume covers such topics as Beta-Structures in Fibrous Proteins; B-Silks: Enhancing and Controlling Aggregation; Beta-Rolls, Beta-Helices and Other Beta-Solenoid Proteins; Natural Triple B-Stranded Fibrous Folds; Structure, Function and Amyloidogenesis of Fungal Prions: Filament Polymorphism and Prion Variants; X-Ray Fiber and powder Diffraction of PRP Prion Peptides; From the Polymorphism of Amyloid Fibrils to Their Assembly Mechanism and Cytotoxicity; Structural Models of Amyloid-like Fibrils.
Fungal Allergy and Pathogenicity
The importance of fungal organisms as allergens and pathogens has been increasing considerably over the last decade. This is due, on the one hand, to a general increase in the incidence of allergies, but also to the growing number of immunocompromized individuals such as AIDS patients or transplant recipients. This book summarizes what is currently known about the allergens of Candida, Aspergillus, Cladosporium, Alternaria, Coprinus, and Psilocybe, among others, and describes the application of recombinant allergens for diagnosis and new forms of therapy. The virulence factors and defense mechanisms against Aspergillus and Candida infections are discussed as are the various causes of superfi...
Synthetic Vaccines
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. This volume focuses on synthetic vaccines. - Contributions from leading authorities - Informs and updates on all the latest developments in the field
Advances in Immunology
Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. - Contributions from leading authorities - Informs and updates on all the latest developments in the field
Advances in Protein Chemistry and Structural Biology
Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale. - Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy - Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission
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Physico-chemical Aspects of Textile Coloration
The production of textile materials comprises a very large and complex global industry that utilises a diverse range of fibre types and creates a variety of textile products. As the great majority of such products are coloured, predominantly using aqueous dyeing processes, the coloration of textiles is a large-scale global business in which complex procedures are used to apply different types of dye to the various types of textile material. The development of such dyeing processes is the result of substantial research activity, undertaken over many decades, into the physico-chemical aspects of dye adsorption and the establishment of ‘dyeing theory’, which seeks to describe the mechanism ...
Intrinsically Disordered Proteins
In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
