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Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.
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Much has been learned about the subject of noise and random fluctuations over the last 170 years (some old milestones: Brownian motion, 1826; Einstein's diffusion theory, 1905; Johnson-Nyquist thermal noise, 1926), but much remains to be known. This volume will be interesting reading for physicists, engineers, mathematicians, biologists and PhD students. The invited papers in the volume survey classical unsolved problems while the regular papers present new problems and paradoxes.
A reexamination of English history from a local point of view. The author attempts to show how the Established Church impinged on the lives of ordinary people in the diocese of Bath and Wells in the period preceding the Civil War. Illustrated.
This updated edition provides clinicians from various backgrounds and levels of training the information needed to optimally diagnose and manage neurologic complications of the nervous system. Organized into seven sections, this comprehensive volume begins with an overview of diagnostic studies for neurologic complications involving the nervous system. That is followed by sections on metastatic and non-metastatic complications of cancer involving the nervous system, and the interpretation, diagnosis, and management of common neuro-oncologic symptoms. The next section reviews the neurologic complications of cancer therapy, including corticosteroids, radiation therapy, chemotherapy, targeted m...