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Galanin
Galanin is a neuropeptide found both in the central and peripheral nervous system. The 29-amino acid peptide (named after its N-terminal glycine and C-terminal alanine) was identified in 1983 by its C-terminal amidation. This 'reverse' approach, that is to discover a substance through a distinct chemical feature, and only subsequently to characterize its biological activity, was novel and has been successful in the identification of several other peptides. After the structure of galanin was determined in 1983, functional studies were performed with material purified from natural sources until the synthetic form of the peptide became available. Galanin can act as transmitter, modulator and tr...
Involvement of Bioactive Peptides in the Control of Cell Survival, Proliferation and Plasticity in Physiological and Pathological Conditions, 2nd Edition
Publisher’s note: In this 2nd edition, the following article has been added: “Editorial: Involvement of Bioactive Peptides in the Control of Cell Survival, Proliferation and Plasticity in Physiological and Pathological Conditions”
The End of Mental Illness
Dr. Daniel Amen offers evidence-based approach to preventing and treating conditions like anxiety, depression, ADHD, addictions, PTSD, bipolar, and more.
Regulatory Peptides in Neuroscience and Endocrinology: A New Era Begins
This Research Topic features recent developments in the field of regulatory peptide physiology and peptide-based therapeutics.
Prospects and Future Tasks of Universities
Universities are undergoing an extraordinary transformation. Digital technologies have altered research and teaching, while modern communication media and social media promote an interactive exchange of information with society that has accelerated international knowledge transfer. At the same time, new educational careers are available in growing higher education fields. How can universities meet these and other challenges? Reputable experts come together in this book to design scenarios for universities in the 21st century. (Series: Research and Science / Forschung und Wissenschaft, Vol. 2) [Subject: Research Studies, Higher Education]
Verteporfin-induced Proteotoxicity Impairs Cell Homeostasis and Survival in Neuroblastoma Subtypes Independent of YAP/TAZ Expression
Abstract: Neuroblastoma (NB) is a highly aggressive extracranial solid tumor in children. Due to its heterogeneity, NB remains a therapeutic challenge. Several oncogenic factors, including the Hippo effectors YAP/TAZ, are associated with NB tumorigenesis. Verteporfin (VPF) is an FDA-approved drug shown to directly inhibit YAP/TAZ activity. Our study aimed to investigate VPF's potential as a therapeutic agent in NB. We show that VPF selectively and efficiently impairs the viability of YAP/TAZ-expressing NB GI-ME-N and SK-N-AS cells, but not of non-malignant fibroblasts. To investigate whether VPF-mediated NB cell killing is YAP-dependent, we tested VPF potency in CRISPR-mediated YAP/TAZ knock...
