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We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Tumor microenvironment (TME) plays an important role in immunosuppressive mechanisms that result in immune editing and treatment resistance. Elucidating the diversity of stromal and immune cell distribution, polarization, and changes in their gene expression signatures will enable a better understanding of key events to improve treatment and prognosis. With the onset of immune checkpoint inhibitors (ICIs) in clinics for patients with solid tumors and hematologic malignancies, immunotherapy has taken a new direction in cancer management, especially as combination therapies. However, limitations encountered with the use of ICIs, including toxicity and immune-related adverse events (irAE) indic...
The exchange of ideas and knowledge concerning cancer prevention and methods forpatient education is essential to giving patients all over the world access to the most up-to-date therapies. Cancer is the third leading cause of death in the United Arab Emirates, accounting for 12% of fatalities. Concerted efforts are now being made to heighten awareness with regard to prevention, screening, early diagnosis and multimodality therapy for advanced disease. Issues addressed in this volume include evidence-based oncology, molecular biology, diagnosis, staging and treatment encompassing chemotherapy, radiation therapy, surgery, novel experimental and therapeutic strategies, and palliative care. Spe...
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"As someone who has spent forty years in psychology with a long-standing interest in evolution, I'll just assimilate Howard Bloom's accomplishment and my amazement."-DAVID SMILLIE, Visiting Professor of Zoology, Duke University In this extraordinary follow-up to the critically acclaimed The Lucifer Principle, Howard Bloom-one of today's preeminent thinkers-offers us a bold rewrite of the evolutionary saga. He shows how plants and animals (including humans) have evolved together as components of a worldwide learning machine. He describes the network of life on Earth as one that is, in fact, a "complex adaptive system," a global brain in which each of us plays a sometimes conscious, sometimes ...