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A Label-free Optical Detection of Pathogens in Isopropanol as a First Step Towards Real-time Infection Prevention
Abstract: The detection of pathogens is a major public health issue. Every year, thousands of people die because of nosocomial infections. It is therefore important to be able to detect possible outbreaks as early as possible, especially in the hospital environment. Various pathogen detection techniques have already been demonstrated. However, most of them require expensive and specific equipment, and/or complex protocols, which, most of the time, involve biochemical reaction and labelling steps. In this paper, a new method that combines microscopic imaging and machine learning is described. The main benefits of this approach are to be low-cost, label-free and easy to integrate in any suitable medical device, such as hand hygiene dispensers. The suitability of this pathogen detection method is validated using four bacteria, both in PBS (Phosphate Buffered Saline) and in isopropanol. In particular, we demonstrated an efficient pathogenic detection that is sensible to changes in the composition of a mixture of pathogens, even in alcohol-based solutions
Biosensors – Recent Advances and Future Challenges
The present book is devoted to all aspects of biosensing in a very broad definition, including, but not limited to, biomolecular composition used in biosensors (e.g., biocatalytic enzymes, DNAzymes, abiotic nanospecies with biocatalytic features, bioreceptors, DNA/RNA, aptasensors, etc.), physical signal transduction mechanisms (e.g., electrochemical, optical, magnetic, etc.), engineering of different biosensing platforms, operation of biosensors in vitro and in vivo (implantable or wearable devices), self-powered biosensors, etc. The biosensors can be represented with analogue devices measuring concentrations of analytes and binary devices operating in the YES/NO format, possibly with logical processing of input signals. Furthermore, the book is aimed at attracting young scientists and introducing them to the field, while providing newcomers with an enormous collection of literature references.
Fracture Mechanics and Crack Growth
This book presents recent advances related to the following two topics: how mechanical fields close to material or geometrical singularities such as cracks can be determined; how failure criteria can be established according to the singularity degrees related to these discontinuities. Concerning the determination of mechanical fields close to a crack tip, the first part of the book presents most of the traditional methods in order to classify them into two major categories. The first is based on the stress field, such as the Airy function, and the second resolves the problem from functions related to displacement fields. Following this, a new method based on the Hamiltonian system is present...
Recueil général des lois et des arrêts
Vols. for 1908-23 include: Bulletin bibliographique and Bulletin des sommaires.
