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Snejanka Mihaylova
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Hot-Melt Extrusion
Hot-melt extrusion (HME) - melting a substance and forcing it through an orifice under controlled conditions to form a new material - is an emerging processing technology in the pharmaceutical industry for the preparation of various dosage forms and drug delivery systems, for example granules and sustained release tablets. Hot-Melt Extrusion: Pharmaceutical Applications covers the main instrumentation, operation principles and theoretical background of HME. It then focuses on HME drug delivery systems, dosage forms and clinical studies (including pharmacokinetics and bioavailability) of HME products. Finally, the book includes some recent and novel HME applications, scale -up considerations ...
Sanitation Safety Planning
"Sanitation Safety Planning (SSP) is a step-by-step risk based approach to assist in the implementation of the 2006 WHO Guidelines for Safe Use of Wastewater, Excreta and Greywater in Agriculture and Aquaculture. The approach can be applied to all sanitary systems to ensure the system is managed to meet health objectives. SSP assists users to: systematically identify and manage health risk along the sanitation chain; guide investment based on actual risks, to promote health benefits and minimize adverse health impacts; provide assurance to authorities and the public on the safety of sanitation-related products and services. The SSP manual is targeted at a variety of users at different levels including; health authorities and regulators, local authorities, wastewater utility managers, sanitation enterprises and farmers, community based organizations, farmers associations and NGOs. SSP brings together actors from different sectors to identify health risks in the sanitation system and agree on improvements and regular monitoring and underscores the leadership role of the health sector."--Publisher's description.
WHO Guidelines for the Safe Use of Wasterwater Excreta and Greywater
Volume 4 of the Guidelines for the safe use of wastewater, excreta and greywater provides information on the assessment and management of risks associated with microbial hazards. It explains requirements to promote the safe use of excreta and greywater in agriculture, including minimum procedures and specific health-based targets, and how those requirements are intended to be used. This volume also describes the approaches used in deriving the guidelines, including health-based targets, and includes a substantive revision of approaches to ensuring microbial safety
Bioactive Compounds from Plant Origin
This new volume explores the importance of phytochemicals from plants in therapeutics, focusing on the extraction of bioactive compounds and their applications in human health. Natural products and their bioactive compounds are increasingly utilized in preventive and therapeutic medication as well as for the production of pharmaceutical supplements and, more recently, as food additives to increase the functionality of foods. The first section of the volume describes recent advances in the extraction of bioactive compounds from various sources. It looks at advanced extraction techniques such as enzyme-assisted, microwave-assisted, ultrasound-assisted, pressurized liquid extraction, and supercritical extraction techniques. Part 2, on bioactive compounds and health claims, covers the roles of different bioactive compounds and their health-promoting potential for lifestyle diseases. This section explains the botany, physical characteristics, uniqueness, uses, distribution, importance, phytochemistry, bioactivities, and future trends of different functional foods.
Demographic Aspects of Migration
Dr. Albert Schmid President of the Federal Office for Migration and Refugees According to the United Nations, about 200 million people of the estimated world population of 6.8 billion are international migrants – that corresponds to about three per cent of the total world population. The proportion of international migrants in the global population has increased only marginally in the last 40 years. But, as a result of global population growth, the absolute number of migrants has increased, and their structure and spatial distribution has changed considerably. A structural shift has taken place primarily in the industrialised countries, where less than 20 per cent of the global workers are...
Cell Death, Inflammation and Oxidative Stress in Neurodegenerative Diseases
Neurogenerative diseases encompass very different pathologies, which can be demyelinating or nondemyelinating, but which have common mechanisms such as cell death, oxidative stress and inflammation. A better understanding of these mechanisms allows the search for biomarkers and targets for new therapies. This special issue brings together different data on Alzheimer's disease, Parkinson's disease, and multiple sclerosis, detailing the mechanisms of cell death (necroptosis, ferroptosis), oxidative stress and inflammation but also the possibilities of neuroprotection via 5 research articles and 6 review articles. The different reviews allow us to take stock of cell death, oxidative stress and neuroinflammation in the context of neurodegenerative diseases but also in relation to other pathologies where these processes are involved.
Managing Arsenic in the Environment
Contains contributions from an international team of key researchers in the field Includes individual country reviews and recent international case studies, giving a broad perspective on the extent and severity of arsenic contamination and poisoning throughout the Asia-Pacific region, where the majority of research has occurred to date. Takes a whole of systems approach, providing a comprehensive picture of the transfer of arsenic from ground water to humans, impacts to human health and management strategies Describes recent technological advances for risk management and remediation
