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C-reactive protein (CRP) is a component of the innate immune system. CRP is synthesized by the liver in response to pro-inflammatory cytokines and the biosynthesis of CRP increases dramatically during acute inflammation. CRP is considered to be a non-specific serum biomarker for inflammatory diseases. The functions of CRP during the inflammatory state, however, have not been defined yet.
We are delighted to present the inaugural Frontiers in Immunology “Women in Cytokines and Soluble Mediators in Immunity” series of article collections. At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and Science, Technology, Engineering and Mathematics (STEM) research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers.
Over recent years, native pentameric C-reactive protein (pCRP) and its biologically active dissociated form, monomer monomeric CRP (mCRP) have assumed an important role in disease development and pathophysiology. In this series, we have highlighted the thoughts and research of the most eminent scientists in the field of CRP research. This eBook is a collection of original articles and reviews on the subject, creating an archive of current knowledge and understanding. This Research Topic provides new findings of the role of CRP in the fields of neuroscience, cardiovascular disease, inflammation, and macular degeneration as well as defined links to stages in pathological disease progression. These articles explain the mechanisms and pathways through which the dissociated mCRP interacts with a variety of cells, and provide possible prognostic implications and new methods for analysis. Over the coming years, the importance and fascination of the active role of CRP in health and disease is set to rise, and we hope this collection will serve as a valuable reference for these future investigations.
The volume gives an excellent overall view of Rodoreda's poetry in the original and in translation, her short stories and novels. A completely annotated, cross-indexed bibliography of the critical work on Rodoreda, accompanied by an analysis of the current state of criticism on her work is included.
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