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Organic Chemistry in Medicine
This book is intended for students in medicine, pharmacy, and dentistry, physicians, dentists, pharmacists, biochemists, and more. It describes organic compounds that are of importance for medicine: heterocycles, alkaloids, carbohydrates, lipids, proteins, enzymes, nucleic acids, and more. Organic chemistry plays a pivotal role in medicine and in developing, synthesizing, and understanding pharmaceutical compounds. It focuses on carbon-containing compounds, which form the backbone of organic molecules. Functional groups within organic molecules modulate the biochemical properties of organic compounds, like stability, solubility, and activity. Organic chemistry is used for designing drug formulations based on disease mechanisms. Short biographies of chemists and scientists, which have rendered services to general and inorganic chemistry in medicine, are given in a person index.
Electrophoresis
Electrophoresis is a straightforward but informative analytical method used in biochemistry, biology and medicine. This book combines a detailed discussion of theory and technical application with an elaborate section on troubleshooting and problem solving in electrophoresis. Therefore the book is an important guide for both students and scientists.
General and Inorganic Chemistry in Medicine
This book is intended for students in medicine, pharmacy, and dentistry, physicians, dentists, pharmacists, biochemists, and more. In General Chemistry, the laws of chemistry, the structure of simple and complex compounds, chemical bonds, solutions, chemical reactions, kinetics, equilibrium, thermodynamics, protolytic and redox processes, and sorption are discussed. In Inorganic Chemistry, chemical elements, inorganic compounds, and their significance for medicine are presented. It is focused on developing metal-based diagnostic and therapeutic agents. The significance of coordination chemistry to modulate enzyme activity is discussed. The production of reactive oxygen species selectively damaging cancer cells is described, too. Short biographies of chemists and scientists, which have rendered services to general and inorganic chemistry in medicine, are given in a person index.
Failure Analysis
The book presents a unique view of failure analysis of high technology devices. It describes capabilities and limitations of many analytical techniques and testing paths and decisions best followed in example failure analysis studies.
Electrophoresis Fundamentals
The electrophoresis techniques are used in medicine, biochemistry, analytical chemistry, and biology to separate soluble and insoluble proteins, nucleic acids, chromosomes, viruses, as well as lysosomes, mitochondria, ribosomes and other cell organelles, red cells, tissue cells, and parasites. This book provides a view over the old electrophoresis techniques, as well as the recent developments in electrophoresis. Electrophoresis Fundamentals is based on the recent book Electrophoresis: Theory and Practice published in 2020 by De Gruyter. The previous book combines theory and technical applications with troubleshooting and problem solving. While Electrophoresis is intended for specialists, Electrophoresis Fundamentals is a book for laboratory technicians, students, biochemists, general practitioners, and more.
High Performance Liquid Chromatography
During the past decade, modern high-performance liquid chromatography (HPLC) utilization has expanded greatly, especially in the quality control of pharmaceutical products in drug quality control laboratories. This book provides an extensive collection of technical information about HPLC-Columns (physicochemical properties and chromatographic characteristics), from various manufacturers, and helps analysts to decide on the ideal approach for their analysis according to the requirements of drug manufacturers specifi cations and the desired Pharmacopeia. In addition, the authors give practical advice on how to prepare mobile phases, choose a suitable detector, and set up an HPLC analysis. This book is comprehensive for the average professional or technician who plans to work with modern HPLC. This book is useful for most Drug Quality Control Laboratories where modern HPLC is utilized. Following a hands-on approach, the book gives key insights into the pharmaceutical applications of HPLC and the latest requirements of the major regulatory agencies such as ICH, FDA, or USP.
Organic Trace Analysis
Organic contaminants even in very low concentrations can have toxic and ecotoxic effects on exposed organisms. Detection and quantification of such trace amounts in diverging matrices (e.g., water, air, soil, food, tissue, organisms) is challenging and great carefulness and strategic thinking is needed to get reliable results along the way from taking samples up to the final analysis. In the 2nd edition, besides revisions of existing chapters, new analytical technologies and recent application examples are presented: non-target mass spectrometric analysis, trace analysis of per- and polyfluoroalkylated "forever chemicals", organophosphorus esters (nerve agents), and micro- and nanoplastic pa...
Spectrophotometric Determination of Vanadium, Chromium and Manganese
The present book is part of series published on Spectrophotometric methods for determination of various transition metals. Since vanadium chromium and manganese are most important industrial metals their analysis using simple and inexpensive methods is of utmost importance. The present book is an important milestone in this area. Most of the methods described are simple yet well evidenced developed by the experts of the area. The book is written in do it yourself style in lucid and comprehensive way so that analyst with no prior expertise can use it. Academia, industry and Pharma sector analyst will be true beneficiaries of this book.
Protein Chemistry
This class-tested textbook gives an overview of the structure and functions of proteins and explains how amino acids form a defined structural entity with specific properties. The authors also introduce modern methods for purification and separation of proteins as well as different techniques for analyzing their structural and functional properties. A separate part of the book is devoted to enzymes and kinetics of enzymatic reactions. New in the second edition: Since the development of computing techniques has evolved considerably during the last few years, the text benefits from the addition of a chapter on the use of computing, particularly on the use of Alpha Fold in protein research. This AI-based software can determine the protein structures from the amino acid sequence with excellent reliability. Also included a discussion on the use of molecular dynamicsand a real life example of protein purification.
