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Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.
This is a nearly complete collection of Chapters that provide an up to date overview of all aspects of Head and Neck cancer. It is written by professionals but is not only intended for other professionals, but students, patients, policy makers, etc. There are so many aspects to this group of diseases that even the most seasoned professional will learn something from having read this book.
The first text to focus solely on quality and safety in radiotherapy, this work encompasses not only traditional, more technically oriented, quality assurance activities, but also general approaches of quality and safety. It includes contributions from experts both inside and outside the field to present a global view. The task of assuring quality
This book constitutes the Third 3D Head and Neck Tumor Segmentation in PET/CT Challenge, HECKTOR 2022, which was held in conjunction with the 25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022, on September 22, 2022. The 22 contributions presented, as well as an overview paper, were carefully reviewed and selected from 24 submissions. This challenge aims to evaluate and compare the current state-of-the-art methods for automatic head and neck tumor segmentation. In the context of this challenge, a dataset of 883 delineated PET/CT images was made available for training.
Image Guided Radiation Therapy (IGRT) is a true revolution in the field of radiation oncology. IGRT provides the unprecedented means of conforming does to the shape of the target tissues in 3-dimensions reducing the risk of complications thereby improving the quality of life of irradiated patients. Moreover, IGRT provides the means to deliver higher than conventional doses thus improving the chance of cure in these patients. Despite its established benefits, several barriers exist to the widespread clinical implementation of IGRT. In the past, great concerns existed regarding the large capital outlay needed for both software and hardware. This barrier is less relevant today given the increased reimbursements possible with IGRT. Today, the most significant barrier is education. IGRT is a fundamentally new approach to both treatment planning and delivery. Adoption of the IGRT approach entails new ways of thinking in regard to patient selection, treatment planning and quality assurance measures. Unfortunately, apart from a few University-based short courses, limited resources are available for the physician and physicist interested in learning IGRT.
In the years from 1980 to 1987, the author of this book was taken into custody to the prison of Diyarbakir, Kurdistan. This striking story is about Adem, a man of Armenian and Kurdish origin and the happenings that he has endured during his time as a prisoner.
Tackling vital issues of politics, identity and experience in performance, this book asks what Shakespeare's plays mean when extended beyond the English language. From April to June 2012 the Globe to Globe Festival offered the unprecedented opportunity to see all of Shakespeare's plays performed in many different world languages. Thirty-eight productions from around the globe were presented in six weeks as part of the World Shakespeare Festival, which formed a cornerstone of the Cultural Olympics. This book provides the only complete critical record of that event, drawing together an internationally renowned group of scholars of Shakespeare and world theatre with a selection of the UK's most celebrated Shakespearean actors. Featuring a foreword by Artistic Director Dominic Dromgoole and an interview with the Festival Director Tom Bird, this volume highlights the energy and dedication that was necessary to mount this extraordinary cultural experiment.
This book discusses the history, physics, fundamental principles, sensing technologies, and characterization of plasmonic phenomenon-based fiber-optic biosensors, using optic-plasmonic sensors as a case study. It describes the plasmonic phenomenon and its application in optical fiber-based sensing, presented based on properties and usage of different nanomaterials spread across nine chapters. Content covers advances in nanomaterials, structural designing, and their scope in biomedical applications. Future developments of biosensing devices and related articulate methods are also described. Features: Gives a comprehensive view on the nanomaterials used in plasmonic optical fiber biosensors Includes synthesis, characterization, and usage for detection of different analytes Discusses trends in the design of wavelength-based optical fiber sensors Reviews micro- and nanostructured biosensing devices Explores application of plasmonic sensors in the biosensing field This book is aimed at researchers and graduate students in Optical Communications, Biomedical Engineering, Optics, Sensors, Instrumentation, and Measurement.
"Hitler, milyonlarca insanı gaz odalarında boğmuş, fırınlarda yakmıştı. İnsan gaz odasında boğulunca, fırında yanınca, bütün acılarını unutur. Artık işkenceleri hayal edemez, acıları duyamaz. İşkencenin vücudunda yarattığı yaralarla dolaşamaz. Ürkek olarak yaşamaz. Kırılan ayağını peşinden sürüklemez. İşkenceye karşı koymadığından utanç duymaz. Ya Diyarbakır askeri cezaevini yaşayan esirler? Kimbilir onlar kaç kez ölmek istemişlerdir? Kimbilir onlar kaç kez bir fırında yanmak, bir gaz odasında boğulmak istemişlerdi? Ölüm çok kolaydı Diyarba kır'da, zor olan yaşamaktı."