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Clem Imrie and Colin Johnson This book stems from an unusual meeting held in The Royal College of Physicians and Surgeons of Glasgow in March 2007. Enthusiastic doctors in the diagnosis and treatment of pancreatic diseases were arranged in small groups to discuss specific unsolved/partially clinical problems and suggest the way forward. In some instances, the recommendations were initial improved longitudinal studies, while in others better double-blind randomized st- ies. The recommendations were then presented on the second day before the total 40 plus participants who added their input. Finally, the mechanics of initiating the proposals were arranged. The editors are most thankful to the ...
This book provides a detailed, up-to-date overview of cystic tumors of the pancreas, with coverage of all aspects of diagnosis and treatment (medical, endoscopic, and surgical). After opening chapters on pathology and classification, cytology, molecular biology, and epidemiology, the role of each of the relevant diagnostic methods is carefully examined. The treatment-related chapters describe surgical approaches, including minimally invasive surgery, as well as ablation modalities and chemo-radiotherapy. Thorough guidance is also provided specifically on the management of cystic tumors in high-risk cases and on follow-up. The authors are global opinion leaders in their field who have contrib...
The busy surgeon will find this unique issue packed with useful, practical information on pancreatic surgery. Topics include the 'borderline resectable' pancreas, pathologic analysis of pancreatic carcinoma, quality metrics, antimicrobial therapy in severe acute pancreatitis, management of pancreatic neuroendocrine tumors, operative management of acute pancreatitis, endoscopic evaluation in acute pancreatitis, familial pancreatic cancer and the genetics of pancreatic cancer, diabetes and pancreatic cancer, and much more!
Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. - Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes - Aids the development of therapeutic treatments for cancer - Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research
This encyclopedia volume covers the complete field of pathology of the pancreas – from Acinar cell neoplasms to Vascular resections. The alphabetically arranged entries, each of which provides a detailed description of a specific pathological disease pattern, allow readers to quickly and easily find the information they need.
Pathology of the Pancreas: A Practical Approach covers all the diagnostic entities in adult pancreatic pathology, providing extensive illustrations and tables to assist the pathologist at the time of diagnostic reporting of histological and cytological specimens. Potential pitfalls and mimics in pancreatic pathology are highlighted and illustrated, and guidance is provided regarding how to recognize and avoid them. Pathology of the Pancreas: A Practical Approach enables the pathologist to recognize the various pathological entities and provide the key information in their pathology reports, which is necessary for the individual patient’s further management. It is based on the most recent diagnostic algorithms, international consensus guidelines, and systems for disease classification, staging and grading. Clinical information is also included, where it is important for the multidisciplinary team management discussion. Pathology of the Pancreas: A Practical Approach is a bench book for everyday use beside the microscope and provides the diagnostic pathologist with a comprehensive, well-illustrated and extensively cross-referenced approach to pancreatic pathology.
This book provides state of the art knowledge on a broad range of clinical issues in pancreatic cancer, covering topics from screening and pathophysiology to surgical treatments. In particular, the focus is on current controversies and on evidence-based surgical techniques. Further aspects considered include the management of precancerous lesions, diagnostic methods, perioperative care and nonsurgical treatment. The description of surgical methods is supported by many helpful illustrations and important technical issues are carefully addressed. Determination of resectability and extent of surgery is also discussed. Based on recent developments in surgical techniques, some surgeons are performing more and more radical operations. It is essential, however, that surgical strategy is based on the best available evidence and surgeons will find that this book offers valuable help in achieving this aim. In addition, it will be a great asset in clinical practice for all who are involved or interested in the management of pancreatic cancer.
This updated volume provides a practical guide to pancreatic pathology that covers recent changes in concepts and classifications. Potential pitfalls and mimics in pancreatic pathology are highlighted and illustrated, and guidance is provided regarding how to recognise and avoid them. There is a new chapter on transplant pathology, and more than 200 new macroscopic and microscopic images have been added. Pathology of the Pancreas: A Practical Approach aims to enable readers to recognise the various pathological entities and provide the key information in their pathology reports, which is necessary for the individual patient’s further management. The book provides the diagnostic pathologist with a comprehensive, well-illustrated, and extensively cross-referenced approach to pancreatic pathology.
This book explores outcome modeling in cancer from a data-centric perspective to enable a better understanding of complex treatment response, to guide the design of advanced clinical trials, and to aid personalized patient care and improve their quality of life. It contains coverage of the relevant data sources available for model construction (panomics), ranging from clinical or preclinical resources to basic patient and treatment characteristics, medical imaging (radiomics), and molecular biological markers such as those involved in genomics, proteomics and metabolomics. It also includes discussions on the varying methodologies for predictive model building with analytical and data-driven ...