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The Innate Immune Receptor Nod1 in Reprogramming the Myeloid Compartment
Colorectal cancer (CRC) represents one of the leading causes of morbidity and cancer-related mortality in the world. While the etiology of CRC is believed to arise from genetic mutations, there is increasing evidence that the host microbiota plays a crucial role in CRC development by modulating the tumor microenvironment (TME). Accordingly, the Nod-like innate immune receptor, Nod1, is involved in the detection of invading bacteria and its expression correlates with advancing stages of human CRC. However, the role of Nod1 in regulating inflammation and pathogenesis of CRC remains unclear. Here, I aimed to understand the mechanisms whereby Nod1 signalling might influence the TME during coliti...
30 Years After
Thirty years after the Argentinian invasion of the Falkland Islands, the war remains a source of continued debate and analysis for politicians, historians and military strategists. Not only did the conflict provide a fascinating example of modern expeditionary warfare, but it also brought to the fore numerous questions regarding international law, sovereignty, the inheritance of colonialism, the influence of history on national policy and the use of military force for domestic political uses. As the essays in this collection show, the numerous facets of the Falklands War remain current today and have ramifications far beyond the South Atlantic. Covering issues ranging from military strategy ...
Birdscapes
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The Guns of Independence
The siege of Yorktown in the fall of 1781 was the single most decisive engagement of the American Revolution. The campaign has all the drama any historian or student could want: the war's top generals and admirals pitted against one another; decisive naval engagements; cavalry fighting; siege warfare; night bayonet attacks; and much more. Until now, however, no modern scholarly treatment of the entire campaign has been produced. By the summer of 1781, America had been at war with England for six years. No one believed in 1775 that the colonists would put up such a long and credible struggle. France sided with the colonies as early as 1778, but it was the dispatch of 5,500 infantry under Comt...
Exocet Falklands
“A fascinating account of three SAS missions to counter the Exocet missile . . . from ill-thought out ideas to near suicidal one-way trips onto enemy soil.”—Soldier Magazine This is a revelatory account of three un-tabulated special forces operations, PLUM DUFF, MIKADO and KETTLEDRUM, that were tasked to destroy Argentina’s Exocet missiles during the 1982 Falkland’s campaign. Interviews with the SAS officer commanding Operation PLUM DUFF, members of the reconnaissance patrol for Operation MIKADO, plus the navigator of the helicopter that flew eight troopers into Tierra del Fuego, has allowed the author to describe the tortuous events that led, instead, to a significant survival sto...
Just a feeling of unsafety
When a mother came to ask to open an inquiry about the missing of her daughter, Joseph Bohmler agreed, but this case of disappearance will bring him in serious troubles that will have unexpected impacts. Follow lieutenant Joseph Bohmler and his group of serious crime squad of National Police onto streets of Valence and its no law zones, in a country on the verge of collapse where violence, theft, assault, rape and murder are considered by the government as just a feeling of unsafety.
Waterfowl 2000
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Politics, Propaganda and the Press
This book examines British and Argentine media output in the prelude to and during the 1982 Falklands/Malvinas Conflict and acknowledges the aftermath and legacies of the media response. Yards of ink have been spilt, reinforcing the view that the Argentine Junta’s action on 2nd April 1982 was a ‘diversion’ from domestic tensions. This view, coupled with the paucity of any thorough, in-depth analysis afforded to Argentine media aspects of the War - particularly the press - necessitates this volume’s copious international study of the Conflict. Uniquely, US media output is also analysed alongside Britain’s and Argentina’s, all drawing upon Cold War historiography and media theory, ...
