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Cyclotides from Brazilian Palicourea Sessilis and Their Effects on Human Lymphocytes
Abstract: Cyclotides are plant-derived peptides found within five families of flowering plants (Violaceae, Rubiaceae, Fabaceae, Solanaceae, and Poaceae) that have a cyclic backbone and six conserved cysteine residues linked by disulfide bonds. Their presence within the Violaceae species seems ubiquitous, yet not all members of other families produce these macrocyclic peptides. The genus Palicourea Aubl. (Rubiaceae) contains hundreds of neotropical species of shrubs and small trees; however, only a few cyclotides have been discovered hitherto. Herein, five previously uncharacterized Möbius cyclotides within Palicourea sessilis and their pharmacological activities are described. Cyclotides we...
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Keeping Mary Close
If you've ever wondered what devotion to Mary is all about, you'll treasure this one-of-a-kind, popular glimpse into the early Church's life, doctrine, and devotion to Our Lady. Through lively stories, teachings of the Church fathers, and evidence from ancient archaeology, the authors invite you to enter the fascinating world of the early Christians, giving you an imaginative glimpse into how they demonstrated their love for Mary through their prayers, art, and daily life. Along the way, you'll gain a deeper understanding of Mary's role in your own life and that of the Church today.
Toxic Legacy
"Toxic Legacy will stand shoulder to shoulder with Rachel Carson’s Silent Spring. [This is] unquestionably, one of the most important books of our time."—David Perlmutter, MD, #1 New York Times bestselling author of Grain Brain and Brain Wash "Urgent and eye-opening, the book serves as a loud-and-clear alarm."—The Boston Globe "A game-changer that we would be foolish to ignore."—Kirkus Reviews (starred) From an MIT scientist, mounting evidence that the active ingredient in the world’s most commonly used weedkiller is contributing to skyrocketing rates of chronic disease Glyphosate is the active ingredient in Roundup, the most commonly used weedkiller in the world. Nearly 300 millio...
GPCR Molecular Pharmacology and Drug Targeting
G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.
Folding of Disulfide Proteins
This book aims to cover the knowledge of protein folding accumulated from studies of disulfide-containing proteins, including methodologies, folding pathways, and folding mechanism of numerous extensively characterized disulfide proteins. Folding of Disulfide Proteins will be valuable supplementary reading for general biochemistry, biophysics, molecular biology, and cellular biology courses for graduate and undergraduate students. This book can also be used for specialized graduate-level biochemistry, biophysics, and molecular biology courses dedicated to protein folding as well as related biological problems and diseases. Will also be of interest to everybody interested in problems related to protein folding, and anyone who is interested in understanding the mechanism of protein misfolding and protein misfolding-related diseases.
Antimicrobial and Anticancer Peptides
In 2014, the World Health Organization (WHO) listed cancer as the second leading cause of death and highlighted antimicrobial resistance as “a key global health challenge” that may, in a worst case scenario, lead to an annual death toll of 10 million by 2050, which would exceed predicted cancer deaths by 20%. Novel promising therapeutic options to reduce morbidity and mortality of both infectious microbial diseases and cancer are being developed based on antimicrobial peptides (AMPs), i.e., evolutionary proven antibiotics that also possess anti-cancer activities. Intriguingly, AMPs and anti-cancer peptides (ACPs) rely typically on novel mechanisms and cellular targets not used by current...
