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Metronomic Chemotherapy
This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
Family Firms in Postwar Britain and Germany
Examines the culture and conduct of six small and medium-sized enterprises (SMEs) in England and West Germany from 1945 to the late-1970s, drawing on numerous archives in Germany and Britain. This is the first book length study that examines the detailed histories of SMEs in a comparative, transnational manner. Emerging from this study is an evaluation of German and British varieties of capitalism in action, showing that they were not fixed or static, but rather have changed considerably as they evolved over time. The German companies studied formed part of the Mittelstand, the family-owned sector which is unique to German-speaking countries. This book explores whether the principles of a cl...
Inhibition of MTORC2/RICTOR Impairs Melanoma Hepatic Metastasis
Abstract: Mammalian target of rapamycin complex 2 (mTORC2) with its pivotal component rapamycin-insensitive companion of mTOR (RICTOR) is the major regulator of AKT phosphorylation and is increasingly implicated in tumor growth and progression. In cutaneous melanoma, an extremely aggressive and highly metastatic disease, RICTOR overexpression is involved in tumor development and invasiveness. Therefore, we investigated the impact of RICTOR inhibition in melanoma cells in vitro and in vivo with special emphasis on hepatic metastasis. Moreover, our study focused on the interaction of tumor cells and hepatic stellate cells (HSC) which play a crucial role in the hepatic microenvironment. In sili...
Revolutionising Medical Imaging with Computer Vision and Artificial Intelligence
This collection aims to explore the transformative potential of computer vision and artificial intelligence (AI) in revolutionizing medical imaging. Medical imaging is still in a state of infancy. The interpretation of medical images is often time-consuming and subject to human error. By leveraging computer vision algorithms and AI technologies, medical imaging can be enhanced with automated analysis, pattern recognition, and predictive modelling, leading to improved accuracy, speed, and clinical outcomes. This collection provides an overview of the current state, challenges, and prospects of integrating computer vision and AI techniques into existing medical imaging technologies. Medical imaging has the potential to create a paradigm shift in healthcare in future enhancing diagnostic accuracy, personalised treatment, and overall patient care. While challenges related to data quality, interpretability, and ethics must be navigated, the future for AI based imaging technology is bright.
Analysis and Computation of Microstructure in Finite Plasticity
This book addresses the need for a fundamental understanding of the physical origin, the mathematical behavior and the numerical treatment of models which include microstructure. Leading scientists present their efforts involving mathematical analysis, numerical analysis, computational mechanics, material modelling and experiment. The mathematical analyses are based on methods from the calculus of variations, while in the numerical implementation global optimization algorithms play a central role. The modeling covers all length scales, from the atomic structure up to macroscopic samples. The development of the models ware guided by experiments on single and polycrystals and results will be checked against experimental data.
Christina, Book 2: The Vision of the Good
The second book continues the story again from the perspective of her mother, Bernadette of Christinas development: the end of her school days, the revelation of her life plan and the impressive start of her work in public.Further topics in Book 2 are: the universal rules of life; how to follow our individual soul path and unfold our personal potential; support from our spiritual companions; practical tips for increasing individual and collective vibration frequency; the silent revolution of unconditional love; the importance of grounding for time-change people; the essential link between lateral thinking and spirituality; holistic science and positive technology; four possible consciousness...
Absurde Angst - Narrationen der Sicherheitsgesellschaft
Mit Vehemenz durchdringen die Anforderungen der Sicherheit die Begegnungsräume von Nachbarschaft und Community. Im Fluss alltäglicher Kommunikation perpetuieren sie Verunsicherung, Krise und Angst; zwischen Ermächtigung und Kontrolle, Fiktion und Realität macht sich Absurdität breit. Im ethnografischen Mitgehen entfaltet die Studie, wie subjektive Erfahrungen und gesellschaftliche Mythologien im gelebten Alltag ineinandergreifen und in einem Spannungsfeld von intimer Verletzlichkeit und Terror die Transformationen zur Sicherheitsgesellschaft vorantreiben. Der Inhalt- Zugänge zu einem liminalen Forschungsraum- Übergänge und Schilderräume- Baustellen. Zur Geschichte der Sicherheitsregime- Die Verunsicherung des Gesprächsanfangs- Innenräume der Nachbarschaft- Angst und Alltagserzählen- Einbruch und Erfahrung- Die absurde Welt der Sicherheit Die ZielgruppenFachpublikum aus den Kultur-, Sozial- und Gesellschaftswissenschaften und die interessierte Öffentlichkeit. Die AutorinKatharina Eisch-Angus ist Professorin am Institut für Kulturanthropologie und Europäische Ethnologie der Universität Graz.
