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SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA
Abstract: Persistence of hepatitis B virus (HBV) infection is due to a nuclear covalently closed circular DNA (cccDNA), generated from the virion-borne relaxed circular DNA (rcDNA) genome in a process likely involving numerous cell factors from the host DNA damage response (DDR). The HBV core protein mediates rcDNA transport to the nucleus and likely affects stability and transcriptional activity of cccDNA. Our study aimed at investigating the role of HBV core protein and its posttranslational modification (PTM) with SUMO (small ubiquitin-like modifiers) during the establishment of cccDNA. HBV core protein SUMO PTM was analyzed in His-SUMO-overexpressing cell lines. The impact of HBV core SU...
Hepatitis B Virus
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Dinosaurs Activities Dover Chunky Book
Although they've been extinct for eons, these mighty beasts continue to wield their power in this pocket-sized collection of activities. Kids can help a lost Triceratops catch up with the herd, learn their ABCs coloring a Diplodocus, spot the differences in an Anatosaurus duo, and enjoy lots of other puzzles. The fun doesn't end there because each illustration can be colored!
Cool Chunky Knits
Get your knit on with this stylish and quick-knitting collection of patterns designed for today's super popular chunked-up yarns and fashions! Knitters from beginner to intermediate levels will enjoy exploring the simple but engaging stitch patterns--easy lace, subtle textures, and fun cables.
Pocket Book of Hospital Care for Children
The Pocket Book is for use by doctors nurses and other health workers who are responsible for the care of young children at the first level referral hospitals. This second edition is based on evidence from several WHO updated and published clinical guidelines. It is for use in both inpatient and outpatient care in small hospitals with basic laboratory facilities and essential medicines. In some settings these guidelines can be used in any facilities where sick children are admitted for inpatient care. The Pocket Book is one of a series of documents and tools that support the Integrated Managem.
Sea Life Activities Dover Chunky Book
A wave of activities awaits colorists and puzzle solvers in this pocket-sized book that's packed with entertainment. Kids can solve the word-code puzzle to find the biggest creature in the aquarium, connect the dots to find a surprise from the sea, blaze underwater trails to guide sea life to food, solve crosswords, and color fifty-five unique fish.
Daily Report
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Working Mother
The magazine that helps career moms balance their personal and professional lives.
They Left Magic in Their Wake
At the end of the world, there will be magic. Earth has been decimated by climate change. Humanity has fractured into isolated tribes. A child born in the southwestern desert of the United States appears to have magical powers, a strict taboo in his part of the world. In four other locations, people discover magical items. No one knows how they work or where they’re from. Although these strange objects capture the imagination, using them is risky and dangerous. The five tribes at the heart of this novel: Southwestern Desert Tribe: Zadie and Nora have fled their tribe where human reproduction is so rare, pregnant women are burned at the stake as witches. Zadie gives birth to triplets, only ...
The Fighting Times of Abe Attell
Abraham Washington Attell (1883-1970) was among the cleverest, most scientific professional boxers ever to enter the ring. The native San Franciscan fought 172 times--with 127 wins, 51 by knockout--and successfully defended his World Featherweight Champion title 18 times between 1906 and 1912, defeating challengers who included Johnny Kilbane and Battling Nelson. Abe's success inspired his brothers Caesar and Monte to take up the sport--Abe and Monte both held simultaneous world titles for a time. This first ever biography covers Attell's life and career. Growing up poor and Jewish in an predominantly Irish neighborhood, he faced his share of adversity and anti-Semitism. He was charged for alleged involvement in the 1919 Black Sox Scandal. The charges were dropped but Attell was branded for the remainder of his life.
