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SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA
Abstract: Persistence of hepatitis B virus (HBV) infection is due to a nuclear covalently closed circular DNA (cccDNA), generated from the virion-borne relaxed circular DNA (rcDNA) genome in a process likely involving numerous cell factors from the host DNA damage response (DDR). The HBV core protein mediates rcDNA transport to the nucleus and likely affects stability and transcriptional activity of cccDNA. Our study aimed at investigating the role of HBV core protein and its posttranslational modification (PTM) with SUMO (small ubiquitin-like modifiers) during the establishment of cccDNA. HBV core protein SUMO PTM was analyzed in His-SUMO-overexpressing cell lines. The impact of HBV core SU...
Amish and Amish Mennonite Genealogies
This encyclopedia for Amish genealogists is certainly the most definitive, comprehensive, and scholarly work on Amish genealogy that has ever been attempted. It is easy to understand why it required years of meticulous record-keeping to cover so many families (144 different surnames up to 1850). Covers all known Amish in the first settlements in America and shows their lineage for several generations. (955pp. index. hardcover. Pequea Bruderschaft Library, revised edition 2007.)
Degrowth & Strategy
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Conditional and Unconditional Conservatism
Julia Nasev examines the impact of conservative accounting numbers on valuation estimates and on real economic decisions such as cost stickiness.
Sufficiency in Business
Businesses want to be sustainable but how can they promote sufficiency? Sufficiency-oriented business models focus on creating sustainable value, promoting reduced resource consumption and adjusting production volumes to planetary boundaries. The contributors to this volume present real-life examples of sufficiency-oriented companies across diverse industries. These experts share their insights on sufficiency strategies in business, barriers and opportunities discovered, and the impact on customer behavioural change. They address the far-reaching changes in business, society, and policy required for this paradigm shift and suggest future research directions.
Flucht aus Auschwitz
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Presse Handbuch
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