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SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA
Abstract: Persistence of hepatitis B virus (HBV) infection is due to a nuclear covalently closed circular DNA (cccDNA), generated from the virion-borne relaxed circular DNA (rcDNA) genome in a process likely involving numerous cell factors from the host DNA damage response (DDR). The HBV core protein mediates rcDNA transport to the nucleus and likely affects stability and transcriptional activity of cccDNA. Our study aimed at investigating the role of HBV core protein and its posttranslational modification (PTM) with SUMO (small ubiquitin-like modifiers) during the establishment of cccDNA. HBV core protein SUMO PTM was analyzed in His-SUMO-overexpressing cell lines. The impact of HBV core SU...
Security in Smart Cities: Models, Applications, and Challenges
This book offers an essential guide to IoT Security, Smart Cities, IoT Applications, etc. In addition, it presents a structured introduction to the subject of destination marketing and an exhaustive review on the challenges of information security in smart and intelligent applications, especially for IoT and big data contexts. Highlighting the latest research on security in smart cities, it addresses essential models, applications, and challenges. Written in plain and straightforward language, the book offers a self-contained resource for readers with no prior background in the field. Primarily intended for students in Information Security and IoT applications (including smart cities systems and data heterogeneity), it will also greatly benefit academic researchers, IT professionals, policymakers and legislators. It is well suited as a reference book for both undergraduate and graduate courses on information security approaches, the Internet of Things, and real-world intelligent applications.
Christmas With A Tycoon: The Italian's Christmas Child / The Greek's Christmas Bride
A Christmas with Consequences...
Enhanced Living Environments
This open access book was prepared as a Final Publication of the COST Action IC1303 “Algorithms, Architectures and Platforms for Enhanced Living Environments (AAPELE)”. The concept of Enhanced Living Environments (ELE) refers to the area of Ambient Assisted Living (AAL) that is more related with Information and Communication Technologies (ICT). Effective ELE solutions require appropriate ICT algorithms, architectures, platforms, and systems, having in view the advance of science and technology in this area and the development of new and innovative solutions that can provide improvements in the quality of life for people in their homes and can reduce the financial burden on the budgets of...
Cognitive Internet of Medical Things for Smart Healthcare
This book aims to provide a detailed understanding of IoMT-supported applications while engaging premium smart computing methods and improved algorithms in the field of computer science. It contains thirteen chapters discussing various applications under the umbrella of the Internet of Medical Things. These applications geared towards IoMT cloud analysis, machine learning, computer vision and deep learning have enabled the evaluation of the proposed solutions.
The Greek's Christmas Bride
A good Greek wife... Coldly ruthless and deeply cynical, Apollo Metraxis has made a career of bachelorhood. But when the inheritance of his father's estate is conditional on a marriage and a child, he is forced to do the unthinkable! Unpolished Pixie Robinson is the world's worst choice of a wife for Apollo. Yet her family's mounting debts leave her defenceless and therefore uniquely suitable. But when the wedding night exposes Pixie's untouched vulnerability, striking a chord in the dark reaches of his heart, Apollo is forced to think again. And that's before he discovers that she's carrying not one – but two Metraxis heirs!
The Italian's Christmas Child (Christmas with a Tycoon, Book 1) (Mills & Boon Modern)
A Christmas Consequence
Technological and Industrial Applications Associated With Industry 4.0
This book includes chapters related to the analysis of cultural differences as a tool to enrich tacit knowledge and make processes more efficient, the factors that influence job satisfaction and the value of social capital as a competitive strategy to achieve productivity and competitiveness of organizations, in addition to research of the utmost importance to discover the facets of the diamond with respect to the symbolic capital of the organizations where Generation Z will work and how it will discover the best time to establish an innovation ecosystem that will influence its work trajectory. Industry 4.0 requires a major paradigm shift, since human capital is a source of competitive advan...
Advances in Soft Computing and Machine Learning in Image Processing
This book is a collection of the latest applications of methods from soft computing and machine learning in image processing. It explores different areas ranging from image segmentation to the object recognition using complex approaches, and includes the theory of the methodologies used to provide an overview of the application of these tools in image processing. The material has been compiled from a scientific perspective, and the book is primarily intended for undergraduate and postgraduate science, engineering, and computational mathematics students. It can also be used for courses on artificial intelligence, advanced image processing, and computational intelligence, and is a valuable resource for researchers in the evolutionary computation, artificial intelligence and image processing communities.
