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Prevalence of Type 1 and Type 2 Diabetes in Children and Adolescents in Germany from 2002 to 2020: A Study Based on Electronic Health Record Data from the DPV Registry
Abstract: Background To provide estimates of the nationwide prevalence of type 1 diabetes (T1D) and type 2 diabetes (T2D) in individuals younger than 20 years of age in Germany from 2002 to 2020 and to identify trends. Methods Data were obtained from the electronic health record "Diabetes Prospective Follow-up Registry (DPV)" specific to diabetes care. Prevalence was estimated based on prevalent cases at the end of each year for the years 2002, 2008, 2014, and 2020 per 100 000 persons assuming a Poisson distribution and directly age- and/or sex-standardized to the population in 2020. Individuals younger than 20 years of age with a clinical diagnosis of T1D or 10-19-year-olds with T2D were el...
Frequency and Characteristics of Diabetes in Lipodystrophies and Insulin Receptoropathies Compared with Type 1 and Type 2: Results from the Multicenter DPV Registry
Abstract: Objective To investigate the frequency, treatment, and outcome of patients with diabetes due to severe insulin resistance syndromes (SIRS). Research Design and Methods Based on data from the multicenter prospective Diabetes Registry DPV, we analyzed diagnosis, treatment, and outcome of 636,777 patients with diabetes from 1995 to 2022. Results Diabetes due to SIRS was documented in 67 cases (62.7% females), 25 (37%) had lipodystrophies (LD) and 42 (63%) had congenital defects of insulin signaling. The relative frequency compared to type 1 diabetes (T1D) was about 1:2300. Median age at diabetes diagnosis in patients with SIRS was 14.8 years (interquartile range (IQR) 12.8-33.8). A to...
Pädiatrische Endokrinologie und Diabetologie
Seit Langem die erste Neuerscheinung zum Thema in deutscher Sprache, vereint das Werk die Subdisziplinen pädiatrische Endokrinologie und Diabetologie. Zwei Fachgebiete, die, trotz aller Eigenständigkeit, alleine schon durch die Weiterbildungsordnung zusammenwachsen. Die Autoren legen bei der Darstellung der Grundlagen sowie sämtlicher Krankheitsbilder großen Wert auf Verständlichkeit und Praxistauglichkeit. Die Herausgeber haben ein hochkarätiges Autorenteam versammelt und bürgen für Aktualität, Qualität und verlässliche Informationen.
Yearbook of Pediatric Endocrinology 2012
The body of knowledge in most medical specialties is rapidly expanding, making it virtually impossible to follow all advances in clinical and basic sciences that are relevant to a given field. This is particularly true in pediatric endocrinology, at the cross-road of pediatrics, endocrinology, development and genetics. Providing abstracts of articles that report the year's breakthrough developments in the basic sciences and evidence-based new knowledge in clinical research and clinical practice that are relevant to the field, the Yearbook of Pediatric Endocrinology 2011 keeps busy clinicians and scientists, pediatric endocrinologists, and also pediatricians and endocrinologists informed on n...
JIMD Reports, Volume 38
JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder. The chapter 'Open-Label Single-Sequence Crossover Study Evaluating Pharmacokinetics, Efficacy, and Safety of Once-Daily Dosing of Nitisinone in Patients with Hereditary Tyrosinemia Type 1 (HT-1)' is open access under a CC BY 4.0 license via link.springer.com.
